Lymphoma Flashcards
1
Q
ALK rearrangements in DLBCL versus ALCL
A
ALK+ DLBCL: CLTC-ALK (aka clathrin-ALK) is most common, resulting in localization of ALK to clathrin-coated pits. Gives a cytoplasmic granular appearance to ALK IHC.
ALK+ ALCL: NPM1-ALK (aka nucleophosmin-ALK) is most common, resulting in diffuse nuclear and cytoplasmic localization on ALK IHC.
