Lymphoma

Question 1

Low grade NHL May transform to aggressive large cell lymphoma:

Answer 1

Transformation associated with aggressive course, short survival .

Question 2

Aggressive type of NHL ,Relapse systemically

Answer 2

if receive only local therapy .

Question 3

Histologically,…………. are most frequently associated with immunosuppression and autoimmune diseases

Answer 3

DLBCLs

Question 4

B” symptoms

Answer 4

(fevers, night sweats, or unexplained weight loss )

Question 5

Laboratory tests required at lymphoma

Answer 5

serum β-2 microglobulin level
serum lactate dehydrogenase (LDH)

Question 6

Positron emission tomography (PET) using 18F-fluorodeoxyglucose(FDG PET) is useful for ……………….

Answer 6

aggressive lymphomas

Question 7

Lumbar puncture in

Answer 7

Burkitt’s
Lymphoblastic
Diffuse

Question 8

BL=burkitt’s lymphoma

Answer 8

tingible body macrophages =“starry sky”

Endemic BLs are EBV positive, whereas the majority of non-endemic BLs are EBV negative

Question 9

Burkitt’s+ diffuse

Answer 9

هردگيان هم HIV هم EBV

Question 10

DLBCL

Answer 10

50% of patients will have an elevated LDH

Most common histologic subtype of NHL diagnosed, representing about one-third of all cases

Question 11

Patients whose tumors (DLBCL)overexpress the……………. might be more likely to relapse than others.

Answer 11

BCL-2 protein

Question 12

Patients with prominent mediastinal involvement are sometimes diagnosed as a separate subgroup having primary mediastinal DLBCL.

Answer 12

This latter group of patients has
A younger median age (i.e., 37 years)
A female predominance (66%).

Question 13

DLBCL

Answer 13

The most popular regimen in the United States is CHOP plus rituximab.

CNS prophylaxis with either intrathecal chemotherapy or high-dose systemic

typically express the B-cell antigens CD19, CD20, and CD79a

Question 14

MALT lymphoma

Answer 14

Most MALT lymphomas are gastric in origin.

Indolent behavior; potentially curable
MALT lymphoma is often localized.

Patients with gastric MALT lymphomas who are infected with H. pylori can achieve remission in the 80% of cases with eradication of the infection.

but molecular evidence of persisting neoplasia is not infrequent.

Question 15

Extranodal Marginal Zone B Cell Lymphoma of Malt Type

gastric association of this lymphoma

Answer 15

Is associated with H.pylori infection

Question 16

Follicular lymphoma

Answer 16

The most common presentation for FL is with new, painless lymphadenopathy

Most patients do not have an elevated LDH or fevers, night sweats, or weight loss.

Question 17

Mantle

لةگشتى خراوتر
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😡😡😡😡😡😡😡😡😡

Answer 17

regularly overexpress the BCL-1 protein, also known as cyclin D1.

The most common presentation is palpable lymphadenopathy, frequently accompanied by systemic symptoms.

with frequent bone marrow and peripheral blood involvement.

Possibly worst of all lymphomas

Question 18

Mycosis fungoides

Answer 18

The skin lesions progress from patch stage to plaque stage to cutaneous tumors.

Develop generalized erythroderma and circulating tumor cells, called Sézary’s syndrome.

common in males and in blacks.

Question 19

Hodgkin’s Lymphoma

Answer 19

Classical HL (cHL)

Nodular lymphocyte predominant HL (NLPHL)
بدوين أخيري (HL),نةشيويةي وة N
common in whites.

is a malignancy of mature B lymphocytes.

Phenotype
CD45 = Leukocyte Common Antigen
CD20 = B-cell marker

Question 20

Reed-sternberg cells (HRS)

Answer 20

By immunohistochemistry they are often PAX-5 positive .

have low to no expression of other B-cell antigens like CD19 and CD20.

They express CD15 and CD30 in 85 and 100% of cases .

Question 21

Hodjkin

Answer 21

Cutaneous disorders such as erythema nodosum.

paraneoplastic cerebellar degeneration and other distant effects on the CNS

nephrotic syndrome.

immune hemolytic anemia and thrombocytopenia

hypercalcemia

Question 22

A concern in hodgkin

Answer 22

Comorbid diagnoses that may impact therapy should be reviewed, including a history of pulmonary disease and congestive heart failure

Question 23

Unfavourable early stage of Hodgkin

Answer 23

Increased LDH, b2-mic, ESR: Worse

Question 24

Treatment of Hodgkin :-

Bulky disease

Advanced stage

Answer 24

Bulky disease: Combination therapy often used:-Chemotherapy plus radiation to bulky mass.

with advanced stage disease treated with chemotherapy alone.

Question 25

The most popular chemotherapy regimens used in Hodgkin’s disease include

Answer 25

doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD)

Question 26

س١١+١٢+٣٠

Answer 26

مهم