lymphoma

Question 1

pathophysiology of Hodgkins vs non-hodgkins

Answer 1

Hodgkins - mature B lymphocytes

non-Hodgkins - mature B, T, NK cells

Question 2

Hodgkin’s characteristics

Answer 2

Reed-Sternberg cells

common in 20s and 80s

cure rate >85%

RF: Epstein-Barr virus

Question 3

Hodgkins symptomatology

Answer 3

nontender lymphadenopathy - bulky, rapidly growing

B symptoms - fever, chills, night sweats, weight loss

Itching, nephrotic syndrome, immune hemolytic anemia, thrombocytopenia, hypercalcemia, lymph pain with alcohol ingestion

Question 4

Hodgkins diagnosis

Answer 4

lymph node biopsy

Question 5

Hodgkins treatment

Answer 5

chemo w/wo radiation

ABVD regimen outpatient (cardio toxic, teratogenic)

Question 6

NHL characteristics

Answer 6

majority of lymphoma cases
occurs at any age
immunosuppression risk

other causes: EBV, HIV, H. pylori, hep C

Question 7

NHL symptomatology

Answer 7

B symptoms

ROS - CV, pulm, GI, CNS symptoms

peripheral adenopathy - no predictable pattern

Question 8

NHL labs

Answer 8

CBC, CMP, LFTs, SPEP, LDH

LDH

HIV teseting and hepatitis panel

Question 9

NHL diagnostics

Answer 9

CT C/A/P

SPECT or PET for certain subtypes

BMBx depending on type

LP depending on type

Question 10

most common metabolic complication of heme malignancies

Answer 10

hypercalcemia

tx w rehydration, diuresis, bisphosphonates, glucocorticoids

Question 11

TLS

Answer 11

hyperuricemia, hyperphosphatemia, hypocalcemia, hyperK

prevention with fluids, allopurinol, close electrolyte monitoring

Question 12

most significant complication of allogenic SCT

Answer 12

GVHD