Lymphoma

Question 1

There are 4 phenotypes of lymphoma in ferrets. What are they, and (briefly) what are they like?

Answer 1

1) peripheral T cell - terrible - 4 month MST
2) Gastric - rare MALT lymphoma, likely helicobacter related, B lymphocytes
3) Cutaneous - still T cell origin, mature lymphocytes, infiltrative, can have excellent px with removal. Feet & extremities. “red feet, definitely treat!”
4) Peripheral B cell - better - 9 month MST

Question 2

Most common labwork finding with ferret lymphoma?

Answer 2

anemia; chemistry will be affected depending on organs involved

Question 3

Most common cause of lymphocytosis on ferret CBC?

Answer 3

Helicobacter. Just to mess with you.

Can have leukemia too; bone marrow biopsy ideal to differentiate.

Question 4

AUS findings with ferret lymphoma:

Answer 4

Abd lymphadenopathy (is nonspecific finding)
Peritoneal effusion
Mottled/hypoechoic nodules in liver or spleen

Question 5

best LN to biopsy for ferret lymphoma

Answer 5

POPLITEAL OR SCAPULAR

Question 6

rabbit breed with a genetic lymphoma predisposition?

Answer 6

“wirehair rabbits” - autosomal recessive; die young of multicentric lymphoma

Question 7

different forms of cutaneous lymphoma in rabbits?

Answer 7

• Epitheliotropic/mycosis fungoides - T cell L in epidermis & adnexa
• Nonepitheliotropic - B cell L in middle-deep dermis; this has a large cel subtype and a “T cell rich B cell” subtype

Question 8

do rabbits get ALL/CLL?

Answer 8

Not as such. They can develop bone marrow/grade 4 lymphoma, which often has a leukemic phase, but isn’t a leukemia as such

Question 9

3 types of thymic cancer in rabbits?

Answer 9

Thymoma (benign mass, mix of lymphoid/epithelial cells)
Thymic carcinoma (malignant & fast-growing)
Thymic lymphoma

Question 10

FNA of a rabbit thymic mass shows mixed small & intermediate lymphocytes + varying epithelial cells. What type of tumor are you dealing with?

Answer 10

Thymoma or thymic carcinoma (can’t distinguish)

Question 11

you often need what test to distinguish type of thymic tumor?

Answer 11

Biopsy

Question 12

what type of treatment does the pink book recc for thymoma?

Answer 12

VMAT form of radiation therapy - MST 2-4 years or permanent remission but hard to find

Question 13

which cells respond fastest to radiation therapy for a thymic tumor?

Answer 13

Lymphocytes shrink quickly, epithelial cells slow to not at all; so response to tx will vary by mix of cell types in patient

Question 14

if a host species for LCMV is clinically affected, what symptoms will you see?

Answer 14

meningitis, hind limb paralysis

Question 15

what is Cavian Leukemia?

Answer 15

type C retroviral-induced leukemia, can cause periph lymphadenopathy

Question 16

possible treatment for lymphoma in GPs?

Answer 16

in general has a v poor px but if you’re going to tx, lomustine + prednisolone may possibly give a longer survival time

Question 17

Elspar IV in a rabbit causes

Answer 17

can cause anaphylactic shock

Question 18

which type of hamster is more likely to get cutaneous lymphoma?

Answer 18

Syrian. epitheliotropic/mycosis fungoides.

Question 19

what is epizootic lymphoma of young hams?

Answer 19

caused by Hamster polyomavirus

introduce virus to naive population, most die, once established, it switches to a skin tumor form that they can survive