Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Immunology > Lymphoid organs & cellular traffic > Flashcards

Lymphoid organs & cellular traffic Flashcards

1
Q

What are the 2 types of lymphoid tissue.

A

Primary (central) and secondary (peripheral)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is primary lymphoid tissue?

A

Tissue where lymphocytes develop (produced, mature, secreted) e.g. bone marrow and thymus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is secondary lymphoid tissue?

A

Tissue where lymphocytes are maintained and adaptive immune responses are initiated e.g. lymph nodes, spleen and MALT (mucosa-associated lymphoid tissue)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are some examples of MALT

A

Tonsils, BALT, appendix, Peyer’s patches

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Where are B and T cells produced and where do they mature?

A

Produced in bone marrow but T cells mature in thymus.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are immune cell precursors

A

Haematopoietic SCs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is a lymph node?

A

Bi-lobed organ lying over the heart and major blood vessels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are the lobules separate by and what do they consist of?

A

Connective tissue trabeculae and contain cortex and medulla

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is a thymocyte?

A

Immature T cell which migrates from bone marrow to thymus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the site of positive selection

A

The cortex - tightly packed with cells containing immature, proliferating thymocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the site of negative selection

A

The medulla - loosely packed with cells containing more mature thymocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the 3 thymic epithelial cells involved in T cell development?

A

Epithelial nurse, cortical, medulllary

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the site of lymphocyte activation by antigen?

A

Peripheral lymph organs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

How do lymphocytes and lymph reutrn to the blood

A

Thoracic duct

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

How do antigens from sites of infection reach lymph nodes

A

Lymphatics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What does CD stand for?

A

Cluster of differentiation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What do T cells express?

A

Th - CD4 (class II) and Tc- CD8 (classI)

18
Q

When do T cells lose expression of CD4 or CD8?

A

When they differentiate

19
Q

What defines B cells?

A

CD19+

20
Q

What do lymph nodes do?

A

Filter and trap antigen from lymph

21
Q

What do the nodes consist of?

A

Cortex (B cell area), paracortex (T cell area) and medulla

22
Q

How do T cells enter a lymph node?

A

Across high endothelial venules in cortex

23
Q

What do T cells do?

A

Monitor antigen presented by macrophages and dendritic cells

24
Q

What do T cells do if they don’t encounter an antigen?

A

Leave node in efferent lymph

25
Q

What do T cells do if they encounter an antigen?

A

Proliferate and differentiate into effector cells

26
Q

What do T cells have on their surface?

A

L-selectin, LFA-1 and chemokine recepotor

27
Q

What binds to L-selectin

A

GlyCAM-1 and CD34 - causes rolling interaction

28
Q

What is LFA-1 activated by?

A

Chemokines bound to ECM.

29
Q

What does LFA-1 bind to?

A

ICAM-1

30
Q

What is diapedesis?

A

When the lymphocyte leaves the blood and enter the lymph node

31
Q

Where do antigens enter the lymph node from?

A

The afferent lymphatic

32
Q

What is the germinal centre?

A

Transient structure of intense proliferation (B cells start proliferating when antigen enters)

33
Q

What are lymphoid follices?

A

Initially loose network of follicular dendritic cells (FDCs) in region rich in B cells

34
Q

How are FDCs different from conventional DCs?

A

Display antigen to B cells (cross link Ag with B cell receptors and form Germinal Centres)

35
Q

What do lymphocytes recirculate between?

A

Bloodstream, lymph nodes and lymphatics

36
Q

What is the largest secondary lymphoid organ

A

The spleen

37
Q

BALT

A

Bronchus-associated lymphoid tissue

38
Q

GALT

A

Gut-associated lymphoid tissue

39
Q

Where are Peyer’s patches found?

A

In the intestinal lining

40
Q

What is an M cell?

A

Specialised epithelial microfold cells that transport antigens into the lymphoid tissue

41
Q

Where are intestinal lymphocytes found?

A

In organised tissues (peyer’s patches) where immune responses are induced OR scattered throughout intestine (epithelium and lamina)

42
Q

HEV

A

High endothelial venule

Immunology (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions