Lymphoid

Question 1

Hairy cell panel

Answer 1

These expressed CD19, CD20 bright , CD79b, CD22, FMC7 and surface lambda.
A secondary panel -for CD25, CD11c, CD103 and CD123, (4 point hairy cell score)

Question 2

Burkett’s flow

Answer 2

CD10+, CD20+, Ki67+ in nearly 100%, TdT-, Bcl2-, Bcl6+, c-MYC+.

Question 3

Earliest T cell antigen that is expressed

Answer 3

CD7

Question 4

DDx for HLA +ve T cells

Answer 4

Rare- T ALL, mf, some peripheral T cell lymphomas

Question 5

Additional antigens CD30, CD10 or CD56, can mean what for T cell disorders

Answer 5

Anaplastic large cell
Angioimmunoblastic
NKcell

Question 6

Ddx for cd5 + ve lymphoma

Answer 6

CLL
Mantls cell
Margjnal zones less commonly

Question 7

Typical lymphocyye respkknse to inflection

Answer 7

CD8 + T-cell population with prominent HLA -DR expression and partial loss of CD7. This

Question 8

Cd 23 negative lymphoma

Answer 8

Lpl
Marginal zone
Mantle cell

Question 9

Cll

Answer 9

Cd 5 cd 19 co exp cd 23 dim cd 20 dim sIg cd 200

neg cd 10 fmc7

Question 10

B pll

Answer 10

a pan-B phenotype . It differs from CLL in showing strong surface immunoglobulin , expression of FMC7 and CD79b and only occasionally expression of CD5 or CD23.