Lymphatic organs

Question 1

Types of lymphoid organs

Answer 1

Primary and secondary

Question 2

Primary lymphoid organs

Answer 2

Bone marrow and thymus

Question 3

All lymphatic cells originate in

Answer 3

Bone marrow

Question 4

Where are two possibilities for a lymphoid progenitor after it has been formed

Answer 4

1. Stay in bone marrow and differentiate into mature naive B cell or 2. Migrate to thymus where it will mature into a naive T-cell

Question 5

What is a thymocyte, and where are most of them found

Answer 5

An immature T-cell found in cortex of thymus (mainly)

Question 6

What the two main structures of the thymus

Answer 6

Cortex, Medulla

Question 7

where are stromal thymic cells located, and what three types of cells can they be

Answer 7

Located amongst immature t cells(thymocytes) in cortex of thymus, epithelial cells, dendritic cells and macrophages all form part of stromal thymic cells

Question 8

what is Hassall’s Corpuscle, what does it do

Answer 8

A secretory gland (paracrine) that secretes chemical signals indicating dendritic cells in thymus to induce activation of T cells

Question 9

What is the main CD in a maturing B cell in bone marrow

Answer 9

CD9

Question 10

Main CD on Hematopoyetic Progenitor. Cytokines for diferentiation into myeloid germline, cytokines for differentiation into lymphoid progenitor

Answer 10

CD48, Myeloid–GM-CFS and G-CSF and IL-3, Lymphoid IL-7

Question 11

Another name for secondary lymphoid organ, whats the main thing that happens in them

Answer 11

Peripheral lyphatic organs, the presentation of antigaens to naive T and B cells completing their activation

Question 12

what is a naive B or T cell, what do they differentiate to with the correct signals?

Answer 12

Differentiated cells that haven’t been presented an antigen yet, with correct signals and interactions the will differentiate into B cells or Effector(cd4+) or Cytotoxic(cd8+) t cells respectively

Question 13

two main types of peripheral lymphoid organs

Answer 13

Organs (spleen, lymph nodes, malt) and Vessels carrying lymph

Question 14

Location of pathogen and active lymphoid organs; a.lymph nodes b. spleen c.Malt

Answer 14

a. tissue, b. blood c. mucosae (gastrointestinal, genitourinary, respiratory, oral and head)

Question 15

Main 2 functions of Lymphatic vessels

Answer 15

Transport of Ag´s and APC’s and drainage of fluid for interstitial space

Question 16

The______Drains the lymphatic system into the_____ of the heart

Answer 16

Thoracic Duct, Vena cava

Question 17

Three layers of lymph node

Answer 17

Outer to inner–Cortex, Paracortex, Medulla

Question 18

Last stop for activated B and T cells or macrophages found in lymph node.

Answer 18

Medula, then leave through efferent lymphatic vessels

Question 19

function of secondaary lymphoid organss

Answer 19

Antigen presentation and thus, activation of naïve B and T cells gas

Question 20

What can we find in cortex of the lymph node

Answer 20

Primary follicles composed of mainly b cells and secondary (mature ) follicles with germinal centers, where B cells differentiate and mutate for clonal selection

Question 21

The t cell zone in lymph nodes and in spleen

Answer 21

Paracortex and periarterial lymphatic space (PALS) respectively

Question 22

naive t and b cells enter through ____ And leave through the ______ APC´s and antigens enter the lymph node through______

Answer 22

artery, efferent lymphatic vessel, afferent lymphatic vessels

Question 23

Two main functions of the spleen

Answer 23

Filtration of blood and thus antigens in blood, erythrocyte clean up

Question 24

What happens in red pulp, What can we find in this pulp

Answer 24

Erythrocytes go here to die, macrophages and erythrocytes can be found here

Question 25

what is lymphocyte recirculation

Answer 25

The continuous flow of naïve lymphocytes coming from bone marrow and thymus to secondary lymphatic organs

Question 26

What do we find in the white pulp

Answer 26

Marginal zone with primary and secondary follicles, we also find the PALS with T cells, we can also find macrophages and other antigen presenting cells

Question 27

4 structures of waldeyers ring

Answer 27

Adenoids, Palatine and tubal tonsils, Lingual tonsils

Question 28

The 3 types of malt (and their respective name if they have one)

Answer 28

Genitourinary Malt, Balt, Galt

Question 29

What are the 4 components of the GALT

Answer 29

Macrophages, T cells, B cells M cells

Question 30

What is a peyer patch

Answer 30

groupings of lymphoid follicles in mucous membranes , basically a cheaper version of lymph nodes

Question 31

what antibodies are produced here, in the cooperation between lymphatic cells in Malt system

Answer 31

IgA, being secreted back into intestinal lumen for the fight i bomb those bitches

Question 32

Name of Galt trap cells, what do they do

Answer 32

M cells, carry antigens from intestinal lumen inside the peyer patch

Question 33

Where are payer’s patches mainly found?

Answer 33

Small intestine