Immune cells Flashcards
what Myeloid derived cells have receptors for IgE, what gene is active when they express these receptors
Eosinophils, Mast cells, and Basophils
What percentage of blood are neutrophil’s, Eosinophils, and basophils
30%, 1-3%, and Less than 1 % respectively
What granulocytes are involved in the allergic immune response
Eosinophils basophils and mast cells
How does our homie Eosinophil help regulate an allergic response
With the release of histaminases and inhibitory molecules for basophils and mast cells
who’s the main culprit in allergic disease
Mast cells
What are the two types of granules found in neutrophils
Specific granules with lysozymes, collagenase, elastases and azurophilic granules with myeloperoxidases, cathelisides, Defensins
I am found inside the neutrophil, and contain lysozymes, collagenase, and elastases ready to deploy when needed
specific granules
Who are the very first responders and present a fast response to chemotaxis
Neutrophils and Macrophages
How is a macrophage involved in both innate and adaptive immunity
Through antigen presentation and phagocytosis
what’s special about the macrophage membrane
cytoplasmic protrusions known as Pseudopodia that form thanks to motile nature(movement of actin filaments in cytoplasm)
who releases IL-10 and TGF-B, and what do they do
Macrophages when activated supplying and anti-inflammatory response and other regulatory signals
signal for initiation of the inflammatory, pyrogenic, vasodilation and chemotactic response in infections, who creates it and what a-is it
IL-1, IL-6, TNF alpha
What des IL-12 and 8 promote (who secretes it, when, and in what type of immune response(innate or adaptive))
Activation of CD4 T lymphocytes and stimulation of gamma interferon release by NK cells
What 5 things do macrophages produce when activated, also say if they are secreted in an innate response or linked to an adaptive response
IL1, 6 and TNF alpha. Growth factors. IL-10 TNF beta Innate…… IL-12,8. Chemokines.
adaptive
What is formed when a macrophage phagocytes a sneaky motherfucker?
A phagosome then phagolysosome (endosome fuses with lysosome and pathogen is digested), this is followed by presentation of antigens on surface thro HLA, and secretion of debris
What is the MHC complex called in humans, what’s it used for
HLA, used in antigen presentation for T and B cell activation
What are the major antigen presenting cells in the body
Dendritic cells and macrophages
Two types of Dendritic cells, do they all originate from bone marrow
Classical DC formed in bone marrow and Follicular DC’s form in lymphatic follicles
What type of HLA is expressed by Classic Dendritic C’s?
HLA type 1 and 2
What dendritic cell shows antigens to B lymphocytes, and T lymphocytes?
B—Follicular dendritic cells T—-classical dendritic cells
How are platelets involved in an immune response?
The are involved in tissue regeneration and response via chemotaxis
What’s special about lymphocyte size and cytoplasm?
Small sized cells with very little cytoplasm due to enlarged nucleus
What happens when a lymphocyte makes contact with antigen, in terms of size, and general type of lymphocyte.
The become larger(almost duplicate in size) begin to proliferate and differentiate into respective mature types
Where are Lymphocytes produced
bone marrow
