lymphadenopathy Flashcards
lymphoid system comes from what embryologically?
mesenchymal yolk islands
the thymus stems from what embryonic structure?
foregut
what happens in the bursa equivalent?
B cell maturation
what are the 2 primary lyphoid organs?
thymus bursa equivalent (includes GALT)
the stroma of primary lymphoid organs: does it contain reticular fibers? what classification of tissue is it?
No reticular fibers
dense tissue (T cells)
no nodules
the stroma of secondary lymphoid organs: does it contain reticular fibers? what classification of tissue is it?
Yes reticular fibers
diffuse(T cells) and nodular (b cells)
what contains Hassal’s corpuscles?
thymus
what type of epithelium makes up the tonsils?
stratified squamous
what causes venous edema?
dec. protein
dec. osmolality
what causes lymphedema?
inc. protein and debris
what is seen in venous edema?
LE ulcers in gaitor distribution, above medial malleolus
hemosiderin build up
what is seen in lymphedema?
hyperkeratosis
stemmers sign- 2nd toe
genetic pattern of primary lymphedema?
AD
what is praecox lymphedema?
birth - 35 yo
F, puberty, left leg
most common
what test can you use for lymphedema?
stemmers sign
when do you see a reed sternberg cell?
hodgkin lymphoma
what do you have an inc. risk of with HL?
herpes zoster
histological findings of HL?
fish flesh appearance
nodular sclerosis
white pulp enlarged in spleen
what happens to T cells in HL?
decreased
what is immunologically seen in burkitts?
+ CD 19,20
+sIg
+CD10,34
c-myc 8:14 translocation
what is immunologically seen in HL?
- CD 19,20
-sIg
+ CD 30, 15, 70
when do you see a starry sky pattern histologically?
burkitts lymphoma
what is the most common NHL?
B cell, diffuse
with B cell diffuse NHL, what are you at inc. risk for?
HIV
what chromosome translocation is seen with burkitts?
8:14
in what lymphnodes do you see sarcoidosis?
lungs and mediastinal
what infiltrates the lungs with sarcoid?
CD 4 T cells
what is seen on xray with sardoid?
potato nodules
what is seen histologically with sarcoid?
asteroid bodies
schaumann bodies
what is sarcoid?
dz causing non caseating granulomas
what is seen on labs with sarcoid?
inc. ACE
Inc. Vit D
burkitts lymphoma is neoplastic proliferation of?
intermediate B cells, CD 20+
burkitt lymphoma is associated with what virus?
EBV
