Lupus SLE1

Question 1

importance of antinuclear antibodies in SLE

Answer 1

main mechanism of dz - cause build up which activates compliment cascade and inflammation

Question 2

Labs to get ANA and mechanisms to detect

Answer 2

can ID ab to dsDNA by binding to a kinetoplast of microorganism CC lucilae (more specific than ELISA but this can also be done for this and ANA)

Question 3

discuss relation between ana lab values and progression of SLE

Answer 3

spike in titer before flare up

Question 4

state the importance of ag ab complexes in SLE with target organs

Answer 4

the main mechanism of SLE is build up of AbAg complexes (ANA and DNA) and build up on things like filter/glomerulus of kidney

blood and proteins in urine

Question 5

what are the immune mechanisms that lead to joint pain, rash, nephritis

Answer 5

build up of IC

Question 6

coombs test and r/t SLE?

Answer 6

RBCS and detect if have self antibodies

Question 7

what is the significance of low c4-c9 complement components?

Answer 7

no pore so no real elimination (MAC) to get rid of IC

Question 8

what is the most common S+S of SLE?

Answer 8

joint pain

Question 9

the antibody in SLE

Answer 9

type 3 hypersensitivity - IgG

Question 10

what is the bond in antidsDNA and DNA?

Answer 10

ionic. phosphate backbone to arg/lys of CD3