Lupus

Question 1

What is lupus?

Answer 1

Chronic multi system autoimmune disease

Question 2

What are the risk factors for lupus?

Answer 2

Female

15-40yo

Question 3

What is the classic presentation of lupus?

Answer 3

Malar rash
Photosensitivity
Myalgia and arthralgia
RAynaud's
Fatigue and fever

Question 4

What are the classification criteria for lupus?

Answer 4

Any 4 of: MD SOAP BRAIN
Malar rash
Discoid rash
Serositis
Oral ulcers
Arthitis
Photosensitivity
Blood features
Renal features 
ANA +
Immunology features
Neuro features

Question 5

What haematological features are associated with lupus?

Answer 5

Anaemia
Leukopenia
Thrombocytopenia

Question 6

What renal features are associated with lupus?

Answer 6

Proteiuria

Cellular casts in urine

Question 7

What immunological features are seen with lupus?

Answer 7

Anti dsDNA
Ro
Smith

Question 8

What neuro features are associated with lupus?

Answer 8

Unexplained seizures/psychosis

Question 9

What investigations are done for lupus?

Answer 9

Antibodies
-ANA
-Anti dsDNA
-Ro
-Smith 
FBC, U&E, CRP, ESR, LFTs
Urinalysis

Question 10

What is the management of lupus?

Answer 10

1. NSAIDs, steroids, hydroxychloroquine

2. Azathioprine/ methotrexate, tacrolimus, ciclosporin, biologics

Question 11

What are some complications associated with lupus?

Answer 11

Lupus nephritis 
Neuropsychiatric lupus 
Infection 
Anaemia of chronic disease
Interstitial lung disease 
Recurrent miscarriage 
CV disease

Question 12

How does neuropsychiatric SLE present?

Answer 12

Optic neuritis
Transverse myelitis
Psychosis