Lung Cancer - Therapy other than surgery Flashcards
What is the ECOG performance status?
0 = fully active 1 = restricted in physically strenous activity but ambulatory 2 = capable of all self care, up and about >50% of the time, unable to work 3 = up and about <50% of the time, capable of limited self care 4 = wheelchair/bed bound
Which type of lung cancer is strongly associated with finger clubbing?
SCC
What is the most common type of lung cancer in non-smokers?
Adenocarcinomas
Where does large cell lung carcinoma typically develop?
Peripherally
It is anaplastic (poorly differentiated tumours with poor prognosis)
What hormone may large cell carcinomas secrete?
b-HCG
What is the maintenance chemo used for NSCLC?
Premetrexed
What targeted drugs can be used for adenocarcinoma with driver mutation?
EGFR - Erlotinib, getitinib, atatinib (TKIs)
ALK translocation - crizotinib, ceritinib
BRAF mutation - vemurafenib, dabrafenib
How is stage I and II NSCLC managed?
1st line - surgery (+/- pre/post-op chemo/chemoradiation
How is stage IIIA NSCLC managed?
Preop chemo/chemoradiation + surgery
How is stage IIIB NSCLC that is resectable with no contralateral adenopathy managed?
Preop chemo/radio + surgery
How is stage IIIB NSCLC that cannot be resected managed?
Chemo
Bevacizumab (monoclonal Ab) or TKI
How is stage IV NSCLC managed?
Chemo + targeted therapy, e.g. pemetrexed
Palliative radio
How is limited SCLC managed?
Combination chemo, e.g. cisplatin + etoposide
Early thoracic RT
Prophylactic cranial irradiation (PCI)
What is the median survival of SCLC in those without treatment?
8 months (16 with)
How is extensive SCLC managed?
4 cycles only of combo chemo
PCI recommended
Single fraction RT if palliating
