Lung Cancer - Therapy other than surgery Flashcards
What is the ECOG performance status?
0 = fully active 1 = restricted in physically strenous activity but ambulatory 2 = capable of all self care, up and about >50% of the time, unable to work 3 = up and about <50% of the time, capable of limited self care 4 = wheelchair/bed bound
Which type of lung cancer is strongly associated with finger clubbing?
SCC
What is the most common type of lung cancer in non-smokers?
Adenocarcinomas
Where does large cell lung carcinoma typically develop?
Peripherally
It is anaplastic (poorly differentiated tumours with poor prognosis)
What hormone may large cell carcinomas secrete?
b-HCG
What is the maintenance chemo used for NSCLC?
Premetrexed
What targeted drugs can be used for adenocarcinoma with driver mutation?
EGFR - Erlotinib, getitinib, atatinib (TKIs)
ALK translocation - crizotinib, ceritinib
BRAF mutation - vemurafenib, dabrafenib
How is stage I and II NSCLC managed?
1st line - surgery (+/- pre/post-op chemo/chemoradiation
How is stage IIIA NSCLC managed?
Preop chemo/chemoradiation + surgery
How is stage IIIB NSCLC that is resectable with no contralateral adenopathy managed?
Preop chemo/radio + surgery
How is stage IIIB NSCLC that cannot be resected managed?
Chemo
Bevacizumab (monoclonal Ab) or TKI
How is stage IV NSCLC managed?
Chemo + targeted therapy, e.g. pemetrexed
Palliative radio
How is limited SCLC managed?
Combination chemo, e.g. cisplatin + etoposide
Early thoracic RT
Prophylactic cranial irradiation (PCI)
What is the median survival of SCLC in those without treatment?
8 months (16 with)
How is extensive SCLC managed?
4 cycles only of combo chemo
PCI recommended
Single fraction RT if palliating
What is adjuvant therapy?
Given post another treatment to boost the success of that treatment
What is neoadjuvant therapy?
Given before another treatment to boost the success of that treatment
