Lung Cancer Pathology 1 Flashcards
Describe what a hamartoma is?
not really a tumor but a mass with all the components from the same organ but misplaced and accumulated in the same place.
Which is more common metastatic lung cancer or primary lung cancer?
Metastatic lung cancer
What is the most common cause of metastatic lung cancer?
breast cancer
On X rays how do metastatic lung cancers typically appear?
as “canon balls” on X-ray
What is the most common presenting symptom of bronchogenic carcinomas?
cough
Name some etiologies os lung cancer.
- cigarette smoking
- radon gas (uranium mining)
- Asbestosis and smoking
- Heavy metals (Arsenic, Ni, and beryllium
Scarring of the lung predisposes one to what type of cancer of the lungs?
adenocarcionoma (scar cancers)
Be able to reproduce slide on the cellular and molecular events in carcinogenesis from tobacco exposure.
Be able to reproduce slide on the cellular and molecular events in carcinogenesis from tobacco exposure.
What are the 2 broad groups which bronchogenic carcinomas are classified as?
SCLC and NSCLC (small cell lung cancers and non-small cell lung cancers respectively)
Which type of bronchogenic carcinomas response poorly to chemo?
NSCLC
Which type of bronchogenic carcinomas are more suited to be treated by surgery?
NSCLC
Which type of bronchogenic carcinomas are more aggressive and metastasize early?
SCLC
Which type of bronchogenic carcinomas are not amenable to curative surgery?
SCLC
Name the types of NSCLC’s.
- squamous cell Ca
- adenocarcinoma - bronchial and bronchioalveolar Ca (most common lung Ca)
- Large cell Ca
Adenocarcinoma has replaced what type of nsclc as the most common primary lung tumor in recent years?
squamous cell carcinoma
What is the most common primary lung cancer in smokers and nonsmokers, women and in the region of scar tissue?
adenocarcionma
Which type of lung carcinomas have the strongest relationship to smoking?
squamous cell carcinoma and small cell caricnoma
Which type of bronchogenic carcinomas are typically located centrally in the lungs?
sq cell carcinomas
small cell carcinomas
What type of bronchogenic carcinomas are located more peripherally in the lungs?
adenocarcinomas
What are the most common symptoms of centrally located tumors?
cough and hemoptysis
Partial obstruction with a centrally located tumor can lead to what complications?
infections/bronchectasis
Complete obstruction due to a centrally located primary tumor can lead to what complication?
atelectasis
What are the major symptoms of a peripherally located tumor?
Dyspnea , Chest Pain ( adeno ca which is peripheral in location)
