Lung cancer, bone mets

Question 1

Features of lung cancer

Answer 1

persistent cough
haemoptysis
dyspnoea
chest pain
weight loss and anorexia
hoarseness
seen with Pancoast tumours pressing on the recurrent laryngeal nerve
superior vena cava syndrome

Question 2

3 main subtypes of non small cell lung cancer

Answer 2

squamous
adenocarcinoma
large cell lung carcinoma

Question 3

squamous non small cell lung cancer

Answer 3

typically central
associated with parathyroid hormone-related protein (PTHrP) secretion → hypercalcaemia
strongly associated with finger clubbing
cavitating lesions are more common than other types
hypertrophic pulmonary osteoarthropathy (HPOA)

Question 4

adenocarcinoma non small cell lung cancer

Answer 4

typically peripheral
most common type of lung cancer in non-smokers, although the majority of patients who develop lung adenocarcinoma are smokers

Question 5

large cell lung carinoma

Answer 5

typically peripheral
anaplastic, poorly differentiated tumours with a poor prognosis
may secrete β-hCG