Lung Cancer

Question 1

p53 / p16 mutation

Answer 1

Squamous cell carcinoma

Question 2

RB / myc gene mutation

Answer 2

Small cell lung cancer

Question 3

EGFR / Kras mutation

Answer 3

Adenocarcinoma of lungs

Question 4

Bronchogenic carcinoma

Answer 4

10-30 years exposure

Question 5

Mesothelioma

Answer 5

25-45 years of exposure

Question 6

WHO classification (2015) Epithelial tumor names

Answer 6

Sq. Cell ca
Adeno. Ca
Large Cell ca
Neuro endocrine ca
Mixed ca
NUT ca
OTHERS

Question 7

Squamous Cell cancer

Answer 7

Presence of keratin
Keratinizing
Non ketatinizing
Basaloid

Question 8

Adenocarcinoma types

Answer 8

Mucin secreting

Lepidic
Ainkar
Papillary
Solid

Question 9

Neuro endocrine ca

Answer 9

DIPNECH
Carcinoid tumour
Small Cell ca
Large Cell ca

Question 10

DIPNECH Full form

Answer 10

Diffuse idiopathic pulmonary neuro endocrine Cell Hyperplasia

Question 11

Chromogranin/synaptophysin/ CD 56 & 57 Arr hint for which type of tumour Cell Diffrentiaion

Answer 11

Neuro endocrine Ca

Question 12

Mixed ca types

Answer 12

Adenosquamous ca
Combined small Cell ca

Question 13

NUT Full form

Answer 13

Nuclear protien in testis

Question 14

Other ca names

Answer 14

Sarcomatous cancer
Giant Cell Cancer
Spindle Cell cancer

Question 15

NUT carcinoma

Answer 15

Mutation of:
NUTM¹ Gene - BRD4 Short arm of chr. 19 p in 70% population
Chr 15q14—›BRD³ (Chr. 9q) in 6% population
Unknown gene - 24% population

Question 16

NUT ca

Answer 16

Can affect any age and any sex
Highly aggressive sheets of monomorphic cells
IHC: speckled nuclear chemistry