Lung Cancer Flashcards

1
Q

What proportion of patients survive 1 year of stage 1 lung cancer?
What about stage 4?

A

83%.

17%.

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2
Q

What percentage of lung cancers are associated with smoking?

A

80%

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3
Q

What other non smoking risk factors are there for lung cancer?

A

Asbestos exposure,
Radon exposure (mining),
Chromium, nickel, arsenic exposure.
Family history.

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4
Q

What classification is used for lung cancer staging?

A

TNM staging.

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5
Q

Which lymph nodes are commonly involved in lung cancer?

A

Hilar lymph nodes,
Mediastinal lymph nodes,
Brachiocephalic lymph nodes.

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6
Q

Where do lung cancers commonly metastasise to?

A

Brain, pleura, liver, adrenals and bone

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7
Q

From what stage are lung cancers considered non operable?

From what stage are they considered terminal?

A

Stage 3a.

Stage 3b and stage 4.

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8
Q

How might the lung cancer be biopsied?

A

Bronchoscopy, USS lymph node or chest wall mass, CT biopsy, thoroscopy, mediastinoscopy.

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9
Q

What additional scans might be done for lung cancer?

A

PET scan - shows sites of metastasis or lymph node involvement.
MRI,
USS,
Bone scan for spinal metastasis,
Echocardiogram for heart function prior to operation.

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10
Q

What symptoms are there for lung cancer?

A

Cough, dyspnoea, wheezing, haemoptysis, chest pain, weight loss, lethargy. Hoarse voice and bloated face suggest metastatic involvement.

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11
Q

What is it important to remember about lung cancer when considering symptoms?

A

Most patients are asymptomatic.

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12
Q

What signs indicate lung cancer?

A

Cache is, horners syndrome, finger clubbing,
Liver enlargement,
Consolidation

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13
Q

What are paraneoplastic syndromes associated with lung cancers?

A
Hypercalcaemia,
Cushing’s syndrome,
SIADH,
encephalopathy,
Pancoast syndrome,
Anaemia,
Finger clubbing.
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14
Q

What investigations are done for all patients with suspected lung cancer?

A

Chest X-ray,

Staging CT scan of chest.

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15
Q

What is the most common type of lung cancer?

What percentage are small cell carcinomas.

A

Non small cell lung cancer (squamous cell or adenocarcinoma) - around 80%.
10% are small cell cancers and 5% are rare tumours.

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16
Q

What mutations have been linked to lung cancer?

A
EGFR,
ALK,
KRAS,
ROS,
PD1,
PDL1.
17
Q

What is PS score?

Why is it relevant?

A

Performance status score, used to assess if treatment of lung cancer would be beneficial. Those with a PS score of 3 or greater would not be biopsied or treated. These people are those that are symptomatic but bedridden or in a chair for more than half of the day.

18
Q

What treatment is best for non small cell cancers?

Why is this not effective for small cell cancers?

A

Surgical resection.

Small cell cancers metastasise rapidly and as such cannot be easily treated with surgery.

19
Q

What treatment is often used for small cell cancers?

A

Combination chemotherapy with potentially curative effect.

20
Q

What is neoadjuvant chemotherapy?

What is adjuvant chemotherapy?

A

Neoadjuvant - used before surgery to reduce tumour stage.

Adjuvant - used after surgery to ensure removal of all cancer. Ineffective if greater than stage 2.

21
Q

What therapies are most promising going into the future?

A

Biological therapies targeting the mutation markers EGFR and KRAS etc.