Lung Anatomy (Week 4) Flashcards
During embryological development, which structure gives rise to the lungs?
Foregut
In which body cavity are the lungs located?
Pleural
What are the two layers of the lateral plate mesoderm?
- Parietal (somatic) layer
- Visceral (splanchnic) layer
What is the primary origin of the epithelium of the internal lining in the larynx, trachea, bronchi, and lungs?
endoderm
What develops from the splanchnic mesodermal origin in the lungs?
Cartilaginous, muscular, and connective tissue components of the trachea and lungs
What are the tracheoesophageal ridges?
Longitudinal ridges that develop as the lung bud expands caudally
What forms the tracheoesophageal septum?
Fusion of tracheoesophageal ridges
What is esophageal atresia?
When the proximal esophagus does not connect with the distal part, creating a blind-ending tube
Often causes difficulty swallowing/digesting; if you swallow anything, it just sits in the dead end part of the tube
What is a tracheoesophageal fistula?
an abnormal connection between the trachea and the esophagus
How many secondary bronchi form from the right primary bronchus?
Three
These will become the three lobes of the lungs
How many secondary bronchi form from the left primary bronchus?
Two
**What separates the pericardioperitoneal canals from the peritoneal and pericardial cavities?
- Pleuroperitoneal folds
- Pleuropericardial folds
What is the pleural cavity?
Space between the parietal and visceral pleura
What is the role of pleural fluid?
Lubricates and facilitates gliding movement of the lungs during breathing
What is pneumothorax?
- Condition where air enters the pleural space, often from chest trauma
- breaks the coupling between parietal and visceral pleura –> leads to an equalization between pleural pressure and atmospheric pressure
- ultimately leading to a collapsed lung
What is a hemothorax?
When blood fills the pleural space
What are pleural recesses?
Note: Lung does not fill the entire pleural sac during quiet respiration
The areas with incomplete filling = pleural recesses
Note: pleural fluid accumulates here during quiet breathing
Note: During deep breaths, expanded lungs push into recesses –> costodiaphragmatic recess & costomediastinal recess
What are the lobes of the right lung?
- Superior
- Middle
- Inferior
What are the lobes of the left lung?
- Superior
- Inferior
What is the hilum of the lung?
Location where blood vessels, air passages, lymphatics, and nerves enter and leave the lungs
What is the dual circulation in the lungs?
- Bronchial Circulation
- Pulmonary Circulation
What does the pulmonary plexus provide?
Both parasympathetic and sympathetic innervation to the lung
What is the primary control for bronchial dilation?
Epinephrine from the adrenal gland
What are the components of the bronchial tree?
- Trachea
- Primary bronchi
- Secondary bronchi
- Tertiary bronchi
- Conducting bronchioles
- Terminal bronchioles
- Respiratory bronchioles
- Alveoli
What structure begins at the cricoid cartilage and bifurcates into right and left primary bronchi?
Trachea
What is the carina?
Internal ridge at tracheal bifurcation into primary bronchi
What is a bronchopulmonary segment?
A region of the lung supplied by a tertiary (segmental) bronchus
ChatGPT: “A bronchopulmonary segment is the smallest functionally independent unit of the lung, supplied by its own tertiary (segmental) bronchus and segmental artery, but drained by shared veins and lymphatics. It is separated from other segments by connective tissue and can be surgically removed without affecting adjacent segments. Each lung has 10 segments, though some fuse in the left lung”
What are the nasal cavities covered by?
Mucosa with lamina propria and bony projections called conchae
What is the purpose of the blood flow in the nasal cavities?
Releases heat to warm and humidify the air
What is the function of type II alveolar epithelial cells?
Produce surfactant, a fluid that lowers surface tension at the air–alveolar interface
What is Infant Respiratory Distress Syndrome (IRDS)?
Insufficient surfactant leads to high surface tension, risking alveolar collapse during expiration
Note: formerly known as hyaline membrane disease
Note: Common cause of death, accounting for ~20% of newborn deaths
What is the innervation for the parietal pleura lining the central portion of the diaphragm?
Phrenic nerves
What type of neurons innervate the visceral pleura?
Visceral sensory neurons
What is the role of surfactant at birth?
Prevents the development of high surface tension and collapse of alveoli
What are the two cavernous chambers within the skull called?
Nasal Cavities
They are separated by the osseous nasal septum.
What is the function of blood flow in the nasal cavities?
Counteracts the direction of inspired air, releasing heat to warm and humidify the air.
What aids in humidification of the air in the nasal cavities?
Water secreted from small seromucous glands.
What type of epithelium covers the middle and inferior conchae?
Respiratory epithelium.
Olfactory epithelium covers the superior conchae
What is the role of Immunoglobulin A in the nasal cavities?
Helps inactivate microorganisms.
What type of epithelium covers the roof of the nasal cavities?
Specialized olfactory epithelium.
What structures filter particulate material from inspired air?
Vibrissae
vibrissae = moist hairs
Note: the vibrissae are found in the external dilated vestibule of the nasal cavities (aka the front part of the nostrils where air first enters)
What type of epithelium transitions from keratinized to non-keratinized in the nasal cavity?
Pseudostratified columnar epithelium.
Note: the internal nasal cavity contains the non-keratinized form and the external dilated vestibule contains the keratinized form
What are the cell types present in respiratory epithelium?
- Ciliated cells
- Goblet cells
- Brush cells
- Small Granule Cells
- Basal Cells
What type of cells are olfactory neurons?
Bipolar neurons.
What do the cilia of olfactory neurons project into?
The aqueous layer
What type of epithelium lines the nasopharynx?
Respiratory epithelium.
What type of epithelium is found in the oropharynx?
Nonkeratinized stratified squamous epithelium.
Rigid wall reinforced by hyaline cartilage (thyroid, cricoid, and inferior arytenoid cartilages) and smaller elastic cartilages (epiglottis, cuneiform, corniculate, and superior arytenoid cartilages)
larynx
What is the function of the epiglottis?
Prevents swallowed food or fluid from entering the air passage.
What type of epithelium covers the vocal folds?
Nonkeratinized stratified squamous epithelium
What reinforces the tracheal wall?
about a dozen C-shaped rings of hyaline cartilage
Note: The cartilage rings keep the tracheal lumen open
Note: Trachealis muscle closes this wall posteriorly
What type of epithelium lines the bronchioles?
Ciliated pseudostratified columnar epithelium in larger bronchioles, transitioning to simple cuboidal in smaller ones.
What do club cells secrete?
Surfactant lipoproteins and mucins.
What are the primary functions of the alveoli?
- Site of gas exchange
- Exchange of O2 and CO2 with the blood in surrounding capillaries
What is the respiratory membrane composed of?
- Type I and Type II pneumocytes
- Fused basal laminae
- Thin capillary endothelial cells.
Boyle’s Law
The volume of an object and the pressure of gas it contains are inversely proportional when temperature remains constant.
______________ (Quiet/Forced) expiration is a largely passive process. As inspiratory muscles relax, the diaphragm ascends, the rib cage descends, and elastic lung tissue recoils.
Quiet
What are accessory muscles of respiration involved in?
Inspiration and expiration
See accessory muscles in the chart