Lung

Question 1

Which cancers peripheral and which central?

Answer 1

Adeno and large peripheral

Squamous and small central

Question 2

Which cancer does hypercalacemia?

Answer 2

squamous

Question 3

Which cancer does LEMS?

Answer 3

Small cell

Question 4

Which cancer does cerebellar ataxia?

Answer 4

Small cell

Anti Hu, Yo, P/Q ab

Question 5

Which cancer does limbic encephalitis?

Answer 5

Small cell

Anti Hu, CRMP5, ANNA5

Question 6

Which cancer does cushing from ACTH?

Answer 6

Small cell

Question 7

Which cancer does HPOA?

Answer 7

squamous

clubbing with periostitis of small hand joints, joint swelling

Question 8

Clubbing Which cancer does?

Answer 8

Non small cell

Question 9

Who gets prophylactic CI?

Answer 9

limited and extensive stage small cell

Question 10

What do you need the FEV1 and DLCO to be at before resect?

Answer 10

At 80% of predicted

Question 11

Is carcinoid of the lung associated with smoking?

Answer 11

No

And very rarely get carcinoid syndrome

Question 12

Lung cancer type presentation with PAIN that is dull and unrelenting,,,,?

Answer 12

Mesothelioma.

Pleura is painful

Question 13

Verbal outline of small cell treatment?

Answer 13

Limited stage - chemo-radio concurrent with platinum based radio

+PCI

Extensive stage give chemo
+PCI
+ if good response but residual disease in thorax- radiotherapy

Question 14

What is counted as extensive stage?

Answer 14

Tumour beyond the boundaries of limited disease including distant metastases, malignant pericardial, or pleural effusions, and contralateral supraclavicular and contralateral hilar involvement.

Question 15

Outline treatment of non small cell?

Answer 15

1A resect
1B, II - resect and adjuvant chemo
If positive resection margins then do some RT

Stage III or IV
-Driver mutation- do that
-No driver mutation - cytotoxic chemo + bevacizumab if non-squamous
-once progress try non cross resistant agents
or anti-PD1

Question 16

strongest smoking association

Answer 16

small cell

Question 17

which makes ectopic TSH–>hyperthyroidism?

Answer 17

squamous

Question 18

If SIADH not getting better with fluid restriction, check

Answer 18

ANP- ectopic can do this

Question 19

carcinoid tumour and smoking

Answer 19

NO association

endobronchial lesion

Question 20

non squamous and chemo; can also give

Answer 20

Bevacizumab

Question 21

PD1 in lung cancer?

Answer 21

Non small cell and no driver mutation

Question 22

most common organ involved in scleroderma

Answer 22

oesophagus

then lung

Question 23

Most common lung cancer is

Answer 23

adenoca

Question 24

what does the trial about lung cancer screening show

Answer 24

age 55 to 74 and smoked 30 PY and still smoking or stopped in last 15 years- low dose annual CT

Question 25

What does micro of lung cancer with thyroid transcription factor staining tell you?

Answer 25

Adeno

TTF)

Question 26

What does lack of staining for cytokeratin 7 and 20 tell you

Answer 26

squamous cell (others may be positive for CK7)

Question 27

things that can cause PET negative

Answer 27

DM
lesion under 8mm
concurrent infection

Question 28

Why no Bev in squamous cell?

Answer 28

bleeding risk

Question 29

What PFT stuff to make sure safe to resect

Answer 29

pneumonectomy FEV1 must be over 80% predicted
lobectomy FEV1 must be over 1.5 L
must have DLCO over 40%
VO2Max under 15ml/kg predicts higher complication rate

Question 30

asbestos increases what kinds lung cancer

Answer 30

NSCLC

NO association with small cell