Lower GI pathology Flashcards
The turnover of the large is faster than the small, true or false
False,
Large 7 days
Small is 4-5 days
How is the small and large bowel peristalsis mediated in terms in innveration
Intrinsic- myenteric
Extrinsic- autonomic
What’s ar the different plexus of the myenteric plexus
Meisseners plexus
Auerbach
Where is the meisseners plexus located
Base of submucosa
Where is th Auerbach plexus located
Betweeen the inner circular and outer longitudinal layers of muscularis propria
List the different pathological features of IBD
UC CD RC Ischemic colitis Appendicitis *if you don’t know what these stand for get yo shite together
What does it mean by “idiopathic IBD”
Does not need infective primer
It’s your immune system usually going fucking mental
Of IBD what are the two main diseases
CD and UC
What is a disease associate with NOD2 gene
CD
What is a disease assoicated with HLA gene
UC
How might someone with suspected IBD be diagnosed
Clinical history
Radiography examination CT
Blood to detect antibody pANCA
Patients with positive pANCA is more likely to be CD, true or false
False,
CD -11%
UC- 75
Describe a clinical profile for someone with UC
Large only No gender bias Peaks 20-30, 70-80 Pancolitis = whole colon Can spread to small= backwash ileitis Appendix can be involved Systemic malformations
What are the histological signs of someone with UC
Ulceration
Limited to mucosa and sub
No granulomatous
Fibrosis
What does having UC and CD increase risk of and why
Cancer
Consistent damage leads to repair therefore more division leading to increased risk of mutation
What are th complications with someone with UC
Haemorrhage >anaemia
Perforation
Toxic dilation
Describe a clinical profile for CD
Any level of GIT again systemic malformations like UC Gender bias, females cause we get every fucking disease Peaks 20-30, 60-70 More common in Jewish Caucasians
When looking at the bowel, what would you see in someone with CD look like
Segements of normal and gross bowel
Histolgoical what are the features of CD
Non- caseating granulomatous
Fibrosis
Need to learn difference between CD and UC
See slide
Can ischemic enteritis effect both large and small instesine
Yes- depends on vessels
What is better acute or chronic occlusion in reference to infarction
Non is smashing
But
A gradual occlusion allows time for the vessels to get there shite together, rearrange and cope “ANASTOMIC CIRCULATION
Acute they be like what’s happening and infarction occurs, this occurs if it happens in the big three
What are the causes of ischemia
Arterial thrombosis
Arterial embolism
Non -occlusive like cardiac failure, so vessels be ok but the heart or blood is not
Where in the large intestine is vunverable to acute ischemia
Splenic fletcher
