LOOP DIURETICS

Question 1

Diuretics Classification

Answer 1

Drugs that modify salt secretion
Proximal CT= Carbonicanhydrase inhibitors=Acetazolamide
Thick Ascending L= loop diuretics= Furesamide
Distal CT= Thiazide= Hydrochlorothiazide
Collecting T= K sparring agents= Spironolactone
Osmotic diuretics = mannitol

Drugs that modify water excretion
ADH agonists( desmopressin )
ADH antagonist
Osmotic diuretics (mannitol )

Question 2

Carbonic anhydrase inhibitors MoA and location of action

Answer 2

Act on Proximal convoluted tubule
Drug name = Acetazolamide

Moa = carbonic anhydrase blocked = HCO3- reabsorbtion blocked = excreted with Na

AA = met Acidosis , sedation , Hyperammonemia in cirrhosis

Question 3

Loop diretics action location
Moa
And drug name

Answer 3

Thick Ascending loop of Henle

Drug name = Furesamide

MoA = inhibit Na/2Cl- transporter in TAL = powerful diuresis and inc Ca excretion

AA = Metabolic Hypokalemia , metabolic alkalosis Ototoxicity , sulfonamide allergy ,hypovolemia

Question 4

Thiazide acts where
Drug name .
Moa

Answer 4

Distal Convulated Tubule
Drug name = Hydrochlorothiazide

MoA = inhibit Na/Ca+ transporter DCT = diuresis and Ca excretion

AA. Metabolic Hypokalemia ,metabolic alkalosis , hyponatremia , efficacy red by NSAIDs , inc serum glucose

Question 5

K sparring agents location

Answer 5

Coritcal collecting ducts CCT
Spironolactone

MOA = red K+ excretion via inhibiting Aldosterone receptors in CCT

AA = HYPERKALEMIA