Loop diuretics Flashcards
1
Q
Name a loop diuretic.
A
Furosemide
2
Q
How does furosemide act?
A
Inhibits Na/K/Cl (NKCC) co transporter and causes excessive urine production as a result of increased Na and K excretion. also increases Ca and Mg excretion.
3
Q
Where do loop diuretics act?
A
Thick ascending limb
4
Q
What are the clinical uses of furosemide?
A
Hyperkalaemia. Hypercalcaemia. Pulmonary oedema due to left ventricular failure.
5
Q
Side effects of loop diuretics include…
A
metabolic alkalosis, hyponatraemia, hypotension, hypovolaemia, hypokalaemia, gout, increased Ca2+ and Mg2+ excretion. Irreversible ototoxicity.
