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PHRM 825 > Long-Term Control Medications in Asthma and COPD > Flashcards

Long-Term Control Medications in Asthma and COPD Flashcards

1
Q

Class: Beclomethasone

A

inhaled corticosteroid

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2
Q

Brand Name: Beclomethasone

A

QVAR

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3
Q

Dosage Form: Beclomethasone

A

Redihaler (MDI)

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4
Q

Age Groups: Beclomethasone

A

5-11 yo, adults

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5
Q

Class: Budesonide

A

inhaled corticosteroids (ics)

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6
Q

Brand Name: Budesonide

A

Pulmicort

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7
Q

Dosage Form: Budesonide

A

Flexhaler

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8
Q

Age Groups: Budesonide

A

5-11 yo, adults

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9
Q

Class: Budesonide Solution

A

inhaled corticosteroids

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10
Q

Brand Name: Budesonide Solution

A

Pulmicort Respules

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11
Q

Dosage Form: Budesonide Solution

A

Nebulizer Solution

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12
Q

Age Group Dosing: Budesonide Solution

A

0-4, 5-11 yo

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13
Q

Class: Ciclesonide

A

inhaled corticosteroid

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14
Q

Brand Name: Ciclesonide

A

Alvesco

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15
Q

Dosage Form: Ciclesonide

A

HFA

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16
Q

Age Group Dosing: Ciclesonide

A

5-11 yo, adults

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17
Q

Class: Fluticasone Propionate

A

inhaled coritcosteroid

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18
Q

Brand Name: Fluticasone Propionate

A

Flovent (HFA, DPI), ArmonAir (Aerosol Powder Inhaler)

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19
Q

Dosage Form: Fluticasone Propionate

A

HFA, DPI, Aerosol Powder Inhaler

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20
Q

Age Group Dosing: Fluticasone Propionate

A

HFA ( 4+ yo)
DPI (4+ yo)
MDPI (adult only)

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21
Q

Class: Fluticasone Furoate

A

inhaled corticosteroids

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22
Q

Brand Name: Fluticasone Furoate

A

Arnuity Ellipta

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23
Q

Dosage Form: Fluticasone Furoate

A

Ellipta

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24
Q

Age Group Dosing: Fluticasone Furoate

A

5-11 yo, adults

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25
Class: Mometasone
inhaled corticosteroid
26
Brand Name: Mometasone
Asmanex
27
Dosage Form: Mometasone
HFA, Twisthaler
28
Age Group Dosing: Mometasone
HFA: 5-11 yo, adult Twisthaler: 4-11 yo, adult
29
Adverse Effects: ICS
oral thrush (candidiasis) cough dysphonia
30
Education Tips: ICS
patients should rinse their mouth and spit after use to prevent oral thrust ICS are most effective long-term control therapy for asthma (improve QOL, increase lung function, and reduce risk of exacerbations) Titrate to lowest effective dose: see low, medium, and high dose conversion tables Pulmicort Respules should use Jet Nebulizer and should not be mixed with other nebulizer medications High doses increase the risk for systemic side effects
31
Uses: ICS
prevent and control inflammation
32
Class: Arformoterol Tartrate
long acting beta agonist (LABA)
33
Brand Name: Arformoterol Tartrate
Brovana
34
Dosage Form: Arformoterol Tartrate
Nebulizing Solution
35
Age Group Dosing: Arformoterol Tartrate
Adults (COPD only)
36
Class: Formoterol
long acting beta agonist (LABA)
37
Brand Name: Formoterol
Perforomist
38
Dosage Form: Formoterol
Nebulizer Solution
39
Age Group Dosing: Formoterol
Adults (COPD only unless used in combination with ICS)
40
Class: Indacaterol
long acting beta agonist (LABA)
41
Brand Name: Indacaterol
Arcapta Neohaler
42
Dosage Form: Indacaterol
Neohaler
43
Age Group Dosing: Indacaterol
Adults (COPD only)
44
Class: Olodaterol
long acting beta agonist (LABA)
45
Brand Name: Olodaterol
Striverdi Respimat
46
Dosage Form: Olodaterol
Respimat
47
Age Group Dosing: Olodaterol
Adult (COPD only)
48
Class: Salmeterol
long acting beta agonist (LABA)
49
Brand Name: Salmeterol
Serevent
50
Dosage Form: Salmeterol
Diskus
51
Age Group Dosing: Salmeterol
4+ yo, adults
52
Adverse Effect: Long Acting Beta Agonists (LABA)
tachycardia headache tremor hypokalemia
53
Education Tips: Long Acting Beta Agonists
Boxed Warning: increased risk of asthma related death for all monotherapy. LABA should not be used alone for asthma management Boxed Warning: increasing hospitalizations in pediatric and adolescent patients Prolonged QT seen with intentional overdoses Not for acute symptoms May be helpful for exercise induced bronchospasm Formoterol and indacaterol capsules should not be taken orally Pediatric Considerations: most children > 4 yo cannot provide sufficient inspiratory flow for adequate lung delivery with a DPI
54
Use: Long Acting Beta Agonist (LABA)
increase cAMP bronchial smooth muscle relaxation and inhibit hypersensitivity mediators from mast cells (histamine and leukotrienes)
55
Class: Aclindium
long acting antimuscarinics (LAMA)
56
Brand Name: Aclindinium
Turdorza Pressair
57
Dosage From: Aclindinium
DPI
58
Age Group Dosing: Aclindinium
Adult (COPD only)
59
Class: Glycopyrrolate
long acting antimuscarinics (LAMA)
60
Brand Name: Glycopyrrolate
Seebri Neohaler
61
Dosage Form: Glycopyrrolate
DPI, Nebulizing Solution
62
Age Group Dosing: Glycopyrrolate
Adult (COPD Only)
63
Class: Revefenacin
long acting antimuscarinics (LAMA)
64
Brand Name: Revefenacin
Yupelri
65
Dosage From: Revefenacin
Nebulizing solution
66
Age Group Dosing: Revefenacin
Adult (COPD only)
67
Class: Tiotropium
long acting antimuscarinics (LAMA)
68
Brand Name: Tiotropium
spirivia
69
Dosage From: Tiotropium
HandiHaler Respimat
70
Age Group Dosing: Tiotropium
Handihaler: Adult (COPD only) Respimat: 6+ yo
71
Class: Umeclidinium
long acting antimuscarinics (LAMA)
72
Brand Name: Umeclinidium
Incruse Ellipta
73
Dosage From: Umeclindinium
DPI
74
Age Group Dosing: Umeclindinium
Adult (COPD only)
75
Adverse Effect: Long Acting Antimuscarinics
dry mouth dizziness blurred vision upper respiratory infections paradoxical bronchospasms
76
Education Tips: Long Acting Antimuscarinics
tiotropium has been approved for use in asthma as an add-on option for children 12+ yo
77
Uses: Long Acting Antimuscarinics
block the bronchoconstrictor effects of acetylcholine on M3 and M2 receptors
78
Class: Fluticasone/Salmeterol
ICS/LABA Combo
79
Brand Name: Fluticasone/Salmeterol
HFA MDI and DPI: Advair Respiclick: AirDuo and AirDuo Digihaler
80
Dosage Form: Fluticasone/Salmeterol
DPI HFA MDI Respiclick
81
Age Group Dosing: Fluticasone/Salmeterol
DPI: 4+ yo, adult HFA: adult Respiclick: adult
82
Class: Budesonide/Formoterol
ICS/LABA
83
Brand Name: Budesonide/Formoterol
Symbicort
84
Dosage Form: Budesonide/Formoterol
HFA MDI
85
Age Group Dosing: Budesonide/Formoterol
5-11 yo, adult
86
Class: Mometasone/Formoterol
ICS/LABA Combo
87
Brand Name: Mometasone/Formoterol
Dulera
88
Dosage Form: Mometasone/Formoterol
MDI
89
Age Group Dosing: Mometasone/Formoterol
Adult
90
Class: Fluticasone/Vilanterol
ICS/LABA
91
Brand Name: Fluticasone/Vilanterol
Breo Ellipta
92
Dosage Form: Fluticasone/Vilanterol
DPI (Ellipta)
93
Age Group Dosing: Fluticasone/Vilanterol
Adult
94
Adverse Effects: ICS/LABA Combo
see individual products
95
Education Tips: ICS/LABA Combo
guidelines recommend combo LABA with ICS in asthma, as LABA should not be used as monotherapy combo products developed to created convenient packaging and assist with patient adherence
96
Class: Olodaterol/Tiotropium
LABA/LAMA Combination
97
Brand Name: Olodaterol/Tiotropium
Stiolto Respimat
98
Dosage Form: Olodaterol/Tiotropium
Respimat
99
Age Group Dosage: Olodaterol/Tiotropium
adult (COPD only)
100
Class: Vilanterol/Umeclidinium
LAMA/LABA Combo
101
Brand Name: Vilanterol/Umeclidinium
Anoro Ellipta
102
Dosage Form: Vilanterol/Umeclidinium
Ellipta
103
Age Group Dosing: Vilanterol/Umeclindium
adult (COPD only)
104
Class: Indacaterol/Glycopyrronium
LABA/LAMA combo
105
Brand Name: Indacaterol/Glycopyrronium
Utibron Neohaler
106
Dosage Form: Indacaterol/Glycopyrronium
Neohaler
107
Age Group Dosage: Indacaterol/Glycopyrronium
adult (COPD only)
108
Class: Formoterol/Glycopyrronium
LABA/LABA combination
109
Brand Name: Formoterol/Glycopyrronium
Bevespi Aerosphere
110
Dosage Form: Formoterol/Glycopyrronium
Aerosphere
111
Age Group Dosing: Formoterol/Glycopyrronium
adult (COPD only)
112
Class: Formoterol/Aclindinium
LABA/LABA combo
113
Brand Name: Formoterol/Aclindinium
Duaklir Pressair
114
Dosage Form: Formoterol/Aclindinium
DPI
115
Age Group Dosing: Formoterol/Aclindinium
Adult (COPD only)
116
Class: Fluticasone/Umeclindinium/Vilanterol
LABA/LAMA/ICS Combo
117
Brand Name: Fluticasone/Umeclindinium/Vilanterol
Trelegy Ellipta
118
Dosage Form: Fluticasone/Umeclindinium/Vilanterol
Ellipta
119
Age Group Dosing: Fluticasone/Umeclindinium/Vilanterol
Adult (COPD and Asthma)
120
Class: Budesonide/Glycopyrrolate/Formoterol Fumarate
LABA/LAMA/ICS
121
Brand Name: Budesonide/Glycopyrrolate/Formoterol Fumarate
Breztri Aerosphere
122
Dosage Form: Budesonide/Glycopyrrolate/Formoterol Fumarate
Aerosphere
123
Age Group Dosing: Budesonide/Glycopyrrolate/Formoterol Fumarate
adult (COPD only)
124
Education Tips: LABA/LAMA
not indicated for treatment of acute deteriorations
125
Class: Cromolyn
Mast Cell Stabilizer
126
Brand Name: Cromolyn
Intal
127
Dosage Form: cromolyn
nebulizer solution
128
Age Group Dosing: Cromolyn
0-4, 5-11 yo, adult
129
Adverse Effect: Cromolyn
high incidence of unpleasant taste in mouth, rare cardiac arrhythmias, coughing, dyspnea, sore throat, N/V/D if absorbed systemically less effective than low-dose ICS prevents increase in bronchial hyperactivity seen in allergy season
130
Class: Montelukast
Leukotriene Modifiers
131
Brand Name: Montelukast
Singulair
132
Dosage Form: Montelukast
tablets granule packts
133
Age Group Dosing: Montelukast
1-11 yo, adult
134
Class: Zafirlukast
Leukotriene Modifiers
135
Brand Name: Zafirlukast
Accolate
136
Dosage Form: Zafirlukast
tablet
137
Age Group Dosing: Zafirlukast
5-11 yo, adult
138
Class: Zileuton
leukotriene modifiers
139
Brand Name: Zileuton
Zyflo CR
140
Dosage Form: Zileuton
IR and ER tablets
141
Age Group Dosing: Zileuton
adult
142
Class: Theophylline
methylxanthines
143
Brand Name: Theophylline
Theochron
144
Dosage Form: Theophylline
ER 12 Hour Tablets ER 24 Hour Tablets ER 24 Hour Capsules Liquid
145
Age Group Dosing: Theophylline
Adult: acute exacerbation, chronic management
146
Adverse Effect: Theophylline
insomnia gastrointestinal upset hyperactivity hypertension tremor
147
Clinical Pearls: Theophylline
Dose Related Toxicity: tachycardia, nausea, vomiting, headache, seizures, arrhythmias CI: peptic ulcer disease, arrhythmias, seizure disorders DI: major substrate of CYP 34A, 1A2, 2E1 Increase Concentration: cimetidine, erythromycin, clarithromycin, ciprofloxacin, ticlopidine Decrease Concentration: phenobarbital, phenytoin, carbamazepine, rifampin, smoking PDE III inhibition likely cause for hypotension, tachycardia, and nausea
148
Uses: methylzanthines
bronchodilation through inhibition of PDE III and PDE IV
149
Class: omalizumab
Anti-Ige
150
Brand Name: omalizumab
Xolair
151
Dosage From: omalizumab
injection solution vial
152
Age Group Dosing: omalizumab
6 yo+
153
Adverse Effect: Omalizumab
headache injection site reactions arthralgia thrombocytopenia pharyngitis sinusitis upper respiratory tract infections
154
Clinical Pearls: omalizumab
Boxed Warning: anaphylaxis do not give more than 150 mg per injection site monitor for anaphylaxis before and after injection FDA approved for moderate to severe persistent asthma in patients with a positive skin test or reactivity to a perennial aeroallergen and symptoms that are inadequately controlled with ICS
155
Class: Mepolizumab
Anti-IL 5
156
Brand Name: Mepolizumab
Nucala
157
Dosage Form: Mepolizumab
autoinjector solution vial
158
Age Group Dosing: mepolizumab
6+ yo
159
Class: reslizumab
Anti-IL5
160
Brand Name: reslizumab
Cinqair
161
Dosage Form: reslizumab
solution
162
Age Group Dosing: Reslizumab
18+ yo
163
Class: Benralizumab
Anti-IL 5
164
Brand Name: Benralizumab
Fasenra
165
Dosage Form: Benralizumab
autoinjector pre-filled syringe
166
Age Group Dosing: Benralizumab
adult
167
Class: Dupilumab
Anti- IL4/IL-13
168
Brand Name: Dupilumab
dupixent
169
Dosage Form: Dupilumab
injection
170
Age Group Dosing: Dupilumab
adult
171
Class: Roflumilast
PDE4 Inhibitor
172
Brand Name: Roflumilast
Daliresp
173
Dosage Form: Roflumilast
Tablets
174
Age Group Dosing: Roflumilast
Adult (COPD only)
175
Adverse Effect: Roflumilast
HA weight loss diarrhea nausea
176
Clinical Pearls: Roflumilast
Monitoring: liver function test, weight DI: cyp3A4 (major), CYP 1A2 (minor) CI: Child Pugh class B or C

PHRM 825 (8 decks)

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