Long-Term Control Medications in Asthma and COPD Flashcards

1
Q

Class: Beclomethasone

A

inhaled corticosteroid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Brand Name: Beclomethasone

A

QVAR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Dosage Form: Beclomethasone

A

Redihaler (MDI)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Age Groups: Beclomethasone

A

5-11 yo, adults

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Class: Budesonide

A

inhaled corticosteroids (ics)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Brand Name: Budesonide

A

Pulmicort

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Dosage Form: Budesonide

A

Flexhaler

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Age Groups: Budesonide

A

5-11 yo, adults

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Class: Budesonide Solution

A

inhaled corticosteroids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Brand Name: Budesonide Solution

A

Pulmicort Respules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Dosage Form: Budesonide Solution

A

Nebulizer Solution

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Age Group Dosing: Budesonide Solution

A

0-4, 5-11 yo

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Class: Ciclesonide

A

inhaled corticosteroid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Brand Name: Ciclesonide

A

Alvesco

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Dosage Form: Ciclesonide

A

HFA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Age Group Dosing: Ciclesonide

A

5-11 yo, adults

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Class: Fluticasone Propionate

A

inhaled coritcosteroid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Brand Name: Fluticasone Propionate

A

Flovent (HFA, DPI), ArmonAir (Aerosol Powder Inhaler)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Dosage Form: Fluticasone Propionate

A

HFA, DPI, Aerosol Powder Inhaler

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Age Group Dosing: Fluticasone Propionate

A

HFA ( 4+ yo)
DPI (4+ yo)
MDPI (adult only)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Class: Fluticasone Furoate

A

inhaled corticosteroids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Brand Name: Fluticasone Furoate

A

Arnuity Ellipta

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Dosage Form: Fluticasone Furoate

A

Ellipta

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Age Group Dosing: Fluticasone Furoate

A

5-11 yo, adults

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Class: Mometasone

A

inhaled corticosteroid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Brand Name: Mometasone

A

Asmanex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Dosage Form: Mometasone

A

HFA, Twisthaler

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Age Group Dosing: Mometasone

A

HFA: 5-11 yo, adult
Twisthaler: 4-11 yo, adult

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Adverse Effects: ICS

A

oral thrush (candidiasis)

cough

dysphonia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Education Tips: ICS

A

patients should rinse their mouth and spit after use to prevent oral thrust

ICS are most effective long-term control therapy for asthma (improve QOL, increase lung function, and reduce risk of exacerbations)

Titrate to lowest effective dose: see low, medium, and high dose conversion tables

Pulmicort Respules should use Jet Nebulizer and should not be mixed with other nebulizer medications

High doses increase the risk for systemic side effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Uses: ICS

A

prevent and control inflammation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Class: Arformoterol Tartrate

A

long acting beta agonist (LABA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

Brand Name: Arformoterol Tartrate

A

Brovana

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

Dosage Form: Arformoterol Tartrate

A

Nebulizing Solution

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

Age Group Dosing: Arformoterol Tartrate

A

Adults (COPD only)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

Class: Formoterol

A

long acting beta agonist (LABA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

Brand Name: Formoterol

A

Perforomist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

Dosage Form: Formoterol

A

Nebulizer Solution

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

Age Group Dosing: Formoterol

A

Adults (COPD only unless used in combination with ICS)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

Class: Indacaterol

A

long acting beta agonist (LABA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

Brand Name: Indacaterol

A

Arcapta Neohaler

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
42
Q

Dosage Form: Indacaterol

A

Neohaler

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
43
Q

Age Group Dosing: Indacaterol

A

Adults (COPD only)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
44
Q

Class: Olodaterol

A

long acting beta agonist (LABA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
45
Q

Brand Name: Olodaterol

A

Striverdi Respimat

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
46
Q

Dosage Form: Olodaterol

A

Respimat

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
47
Q

Age Group Dosing: Olodaterol

A

Adult (COPD only)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
48
Q

Class: Salmeterol

A

long acting beta agonist (LABA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
49
Q

Brand Name: Salmeterol

A

Serevent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
50
Q

Dosage Form: Salmeterol

A

Diskus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
51
Q

Age Group Dosing: Salmeterol

A

4+ yo, adults

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
52
Q

Adverse Effect: Long Acting Beta Agonists (LABA)

A

tachycardia
headache
tremor
hypokalemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
53
Q

Education Tips: Long Acting Beta Agonists

A

Boxed Warning: increased risk of asthma related death for all monotherapy. LABA should not be used alone for asthma management

Boxed Warning: increasing hospitalizations in pediatric and adolescent patients

Prolonged QT seen with intentional overdoses

Not for acute symptoms

May be helpful for exercise induced bronchospasm

Formoterol and indacaterol capsules should not be taken orally

Pediatric Considerations: most children > 4 yo cannot provide sufficient inspiratory flow for adequate lung delivery with a DPI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
54
Q

Use: Long Acting Beta Agonist (LABA)

A

increase cAMP

bronchial smooth muscle relaxation and inhibit hypersensitivity mediators from mast cells (histamine and leukotrienes)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
55
Q

Class: Aclindium

A

long acting antimuscarinics (LAMA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
56
Q

Brand Name: Aclindinium

A

Turdorza Pressair

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
57
Q

Dosage From: Aclindinium

A

DPI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
58
Q

Age Group Dosing: Aclindinium

A

Adult (COPD only)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
59
Q

Class: Glycopyrrolate

A

long acting antimuscarinics (LAMA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
60
Q

Brand Name: Glycopyrrolate

A

Seebri Neohaler

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
61
Q

Dosage Form: Glycopyrrolate

A

DPI, Nebulizing Solution

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
62
Q

Age Group Dosing: Glycopyrrolate

A

Adult (COPD Only)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
63
Q

Class: Revefenacin

A

long acting antimuscarinics (LAMA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
64
Q

Brand Name: Revefenacin

A

Yupelri

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
65
Q

Dosage From: Revefenacin

A

Nebulizing solution

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
66
Q

Age Group Dosing: Revefenacin

A

Adult (COPD only)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
67
Q

Class: Tiotropium

A

long acting antimuscarinics (LAMA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
68
Q

Brand Name: Tiotropium

A

spirivia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
69
Q

Dosage From: Tiotropium

A

HandiHaler
Respimat

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
70
Q

Age Group Dosing: Tiotropium

A

Handihaler: Adult (COPD only)
Respimat: 6+ yo

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
71
Q

Class: Umeclidinium

A

long acting antimuscarinics (LAMA)

72
Q

Brand Name: Umeclinidium

A

Incruse Ellipta

73
Q

Dosage From: Umeclindinium

A

DPI

74
Q

Age Group Dosing: Umeclindinium

A

Adult (COPD only)

75
Q

Adverse Effect: Long Acting Antimuscarinics

A

dry mouth
dizziness
blurred vision
upper respiratory infections
paradoxical bronchospasms

76
Q

Education Tips: Long Acting Antimuscarinics

A

tiotropium has been approved for use in asthma as an add-on option for children 12+ yo

77
Q

Uses: Long Acting Antimuscarinics

A

block the bronchoconstrictor effects of acetylcholine on M3 and M2 receptors

78
Q

Class: Fluticasone/Salmeterol

A

ICS/LABA Combo

79
Q

Brand Name: Fluticasone/Salmeterol

A

HFA MDI and DPI: Advair
Respiclick: AirDuo and AirDuo Digihaler

80
Q

Dosage Form: Fluticasone/Salmeterol

A

DPI
HFA MDI
Respiclick

81
Q

Age Group Dosing: Fluticasone/Salmeterol

A

DPI: 4+ yo, adult
HFA: adult
Respiclick: adult

82
Q

Class: Budesonide/Formoterol

A

ICS/LABA

83
Q

Brand Name: Budesonide/Formoterol

A

Symbicort

84
Q

Dosage Form: Budesonide/Formoterol

A

HFA MDI

85
Q

Age Group Dosing: Budesonide/Formoterol

A

5-11 yo, adult

86
Q

Class: Mometasone/Formoterol

A

ICS/LABA Combo

87
Q

Brand Name: Mometasone/Formoterol

A

Dulera

88
Q

Dosage Form: Mometasone/Formoterol

A

MDI

89
Q

Age Group Dosing: Mometasone/Formoterol

A

Adult

90
Q

Class: Fluticasone/Vilanterol

A

ICS/LABA

91
Q

Brand Name: Fluticasone/Vilanterol

A

Breo Ellipta

92
Q

Dosage Form: Fluticasone/Vilanterol

A

DPI (Ellipta)

93
Q

Age Group Dosing: Fluticasone/Vilanterol

A

Adult

94
Q

Adverse Effects: ICS/LABA Combo

A

see individual products

95
Q

Education Tips: ICS/LABA Combo

A

guidelines recommend combo LABA with ICS in asthma, as LABA should not be used as monotherapy

combo products developed to created convenient packaging and assist with patient adherence

96
Q

Class: Olodaterol/Tiotropium

A

LABA/LAMA Combination

97
Q

Brand Name: Olodaterol/Tiotropium

A

Stiolto Respimat

98
Q

Dosage Form: Olodaterol/Tiotropium

A

Respimat

99
Q

Age Group Dosage: Olodaterol/Tiotropium

A

adult (COPD only)

100
Q

Class: Vilanterol/Umeclidinium

A

LAMA/LABA Combo

101
Q

Brand Name: Vilanterol/Umeclidinium

A

Anoro Ellipta

102
Q

Dosage Form: Vilanterol/Umeclidinium

A

Ellipta

103
Q

Age Group Dosing: Vilanterol/Umeclindium

A

adult (COPD only)

104
Q

Class: Indacaterol/Glycopyrronium

A

LABA/LAMA combo

105
Q

Brand Name: Indacaterol/Glycopyrronium

A

Utibron Neohaler

106
Q

Dosage Form: Indacaterol/Glycopyrronium

A

Neohaler

107
Q

Age Group Dosage: Indacaterol/Glycopyrronium

A

adult (COPD only)

108
Q

Class: Formoterol/Glycopyrronium

A

LABA/LABA combination

109
Q

Brand Name: Formoterol/Glycopyrronium

A

Bevespi Aerosphere

110
Q

Dosage Form: Formoterol/Glycopyrronium

A

Aerosphere

111
Q

Age Group Dosing: Formoterol/Glycopyrronium

A

adult (COPD only)

112
Q

Class: Formoterol/Aclindinium

A

LABA/LABA combo

113
Q

Brand Name: Formoterol/Aclindinium

A

Duaklir Pressair

114
Q

Dosage Form: Formoterol/Aclindinium

A

DPI

115
Q

Age Group Dosing: Formoterol/Aclindinium

A

Adult (COPD only)

116
Q

Class: Fluticasone/Umeclindinium/Vilanterol

A

LABA/LAMA/ICS Combo

117
Q

Brand Name: Fluticasone/Umeclindinium/Vilanterol

A

Trelegy Ellipta

118
Q

Dosage Form: Fluticasone/Umeclindinium/Vilanterol

A

Ellipta

119
Q

Age Group Dosing: Fluticasone/Umeclindinium/Vilanterol

A

Adult (COPD and Asthma)

120
Q

Class: Budesonide/Glycopyrrolate/Formoterol Fumarate

A

LABA/LAMA/ICS

121
Q

Brand Name: Budesonide/Glycopyrrolate/Formoterol Fumarate

A

Breztri Aerosphere

122
Q

Dosage Form: Budesonide/Glycopyrrolate/Formoterol Fumarate

A

Aerosphere

123
Q

Age Group Dosing: Budesonide/Glycopyrrolate/Formoterol Fumarate

A

adult (COPD only)

124
Q

Education Tips: LABA/LAMA

A

not indicated for treatment of acute deteriorations

125
Q

Class: Cromolyn

A

Mast Cell Stabilizer

126
Q

Brand Name: Cromolyn

A

Intal

127
Q

Dosage Form: cromolyn

A

nebulizer solution

128
Q

Age Group Dosing: Cromolyn

A

0-4, 5-11 yo, adult

129
Q

Adverse Effect: Cromolyn

A

high incidence of unpleasant taste in mouth, rare cardiac arrhythmias, coughing, dyspnea, sore throat, N/V/D if absorbed systemically

less effective than low-dose ICS

prevents increase in bronchial hyperactivity seen in allergy season

130
Q

Class: Montelukast

A

Leukotriene Modifiers

131
Q

Brand Name: Montelukast

A

Singulair

132
Q

Dosage Form: Montelukast

A

tablets
granule packts

133
Q

Age Group Dosing: Montelukast

A

1-11 yo, adult

134
Q

Class: Zafirlukast

A

Leukotriene Modifiers

135
Q

Brand Name: Zafirlukast

A

Accolate

136
Q

Dosage Form: Zafirlukast

A

tablet

137
Q

Age Group Dosing: Zafirlukast

A

5-11 yo, adult

138
Q

Class: Zileuton

A

leukotriene modifiers

139
Q

Brand Name: Zileuton

A

Zyflo CR

140
Q

Dosage Form: Zileuton

A

IR and ER tablets

141
Q

Age Group Dosing: Zileuton

A

adult

142
Q

Class: Theophylline

A

methylxanthines

143
Q

Brand Name: Theophylline

A

Theochron

144
Q

Dosage Form: Theophylline

A

ER 12 Hour Tablets
ER 24 Hour Tablets
ER 24 Hour Capsules
Liquid

145
Q

Age Group Dosing: Theophylline

A

Adult: acute exacerbation, chronic management

146
Q

Adverse Effect: Theophylline

A

insomnia
gastrointestinal upset
hyperactivity
hypertension
tremor

147
Q

Clinical Pearls: Theophylline

A

Dose Related Toxicity: tachycardia, nausea, vomiting, headache, seizures, arrhythmias

CI: peptic ulcer disease, arrhythmias, seizure disorders

DI: major substrate of CYP 34A, 1A2, 2E1

Increase Concentration: cimetidine, erythromycin, clarithromycin, ciprofloxacin, ticlopidine

Decrease Concentration: phenobarbital, phenytoin, carbamazepine, rifampin, smoking

PDE III inhibition likely cause for hypotension, tachycardia, and nausea

148
Q

Uses: methylzanthines

A

bronchodilation through inhibition of PDE III and PDE IV

149
Q

Class: omalizumab

A

Anti-Ige

150
Q

Brand Name: omalizumab

A

Xolair

151
Q

Dosage From: omalizumab

A

injection
solution vial

152
Q

Age Group Dosing: omalizumab

A

6 yo+

153
Q

Adverse Effect: Omalizumab

A

headache
injection site reactions
arthralgia
thrombocytopenia
pharyngitis
sinusitis
upper respiratory tract infections

154
Q

Clinical Pearls: omalizumab

A

Boxed Warning: anaphylaxis

do not give more than 150 mg per injection site

monitor for anaphylaxis before and after injection

FDA approved for moderate to severe persistent asthma in patients with a positive skin test or reactivity to a perennial aeroallergen and symptoms that are inadequately controlled with ICS

155
Q

Class: Mepolizumab

A

Anti-IL 5

156
Q

Brand Name: Mepolizumab

A

Nucala

157
Q

Dosage Form: Mepolizumab

A

autoinjector
solution vial

158
Q

Age Group Dosing: mepolizumab

A

6+ yo

159
Q

Class: reslizumab

A

Anti-IL5

160
Q

Brand Name: reslizumab

A

Cinqair

161
Q

Dosage Form: reslizumab

A

solution

162
Q

Age Group Dosing: Reslizumab

A

18+ yo

163
Q

Class: Benralizumab

A

Anti-IL 5

164
Q

Brand Name: Benralizumab

A

Fasenra

165
Q

Dosage Form: Benralizumab

A

autoinjector
pre-filled syringe

166
Q

Age Group Dosing: Benralizumab

A

adult

167
Q

Class: Dupilumab

A

Anti- IL4/IL-13

168
Q

Brand Name: Dupilumab

A

dupixent

169
Q

Dosage Form: Dupilumab

A

injection

170
Q

Age Group Dosing: Dupilumab

A

adult

171
Q

Class: Roflumilast

A

PDE4 Inhibitor

172
Q

Brand Name: Roflumilast

A

Daliresp

173
Q

Dosage Form: Roflumilast

A

Tablets

174
Q

Age Group Dosing: Roflumilast

A

Adult (COPD only)

175
Q

Adverse Effect: Roflumilast

A

HA
weight loss
diarrhea
nausea

176
Q

Clinical Pearls: Roflumilast

A

Monitoring: liver function test, weight
DI: cyp3A4 (major), CYP 1A2 (minor)
CI: Child Pugh class B or C