Local Anesthetics Flashcards

1
Q

Esters

A
  • cause more hypersensitivity reactions

- only 1 letter “i”

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2
Q

Ester durations and potency

A

Short: Procaine (1)
Long: Tetracaine (16)
Topical/Surface: Benzocaine, cocaine (2)

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3
Q

Amides

A

-2 letter “i”s

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4
Q

Amides duration and potency

A

medium: lidocaine (4), mepivacaine (2)

Long: bupivacaine (16), ropivacaine (16)

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5
Q

Esters: Onset and duration

A
  1. Procaine:
    onset: 2-5min
    duration: 25 min to 1 hour
  2. Tetracaine
    onset: <15 min
    duration: 2-3 hours
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6
Q

Amides: onset and duration

A
  1. Mepivacaine
    onset: 3-5 min
    duration: ~1hr
  2. Bupivacaine
    onset: 5 min
    duration: 2-4 hrs
  3. Lidocaine
    onset: <2min
    duration: 30min - 1hr
  4. Ropivacaine
    onset: 10-30min
    duration: ~30min
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7
Q

Local anesthesia MOA

A

block voltage-dependent sodium channels of excitable membrane from sending sensory info to the CNS

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8
Q

Which form of local anesthetic is better/faster at crossing the lipid membrane to reach the cytoplasm receptor site?

A

Non-ionized form

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9
Q

Which form of local anesthetic is the more effective blocking entity once inside the axon?

A

Ionized form

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10
Q

What effect does sodim bicarbonate have when added to a local anesthetic?

A
  1. Accelerates the onset of action

2. Decreases burning sensation

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11
Q

What effect does adding epinephrine (alpha agonist sympathomimetic vasoconstrictor) to a local anesthetic?

A

prolongs duration

long acting don’t need this - bupivicaine, ropivicaine, tetracaine and neither do topical local anesthetics

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12
Q

What is the difference in esters and amides when it comes to metabolism?

A

Esters - metabolized in the blood by plasma cholinesterases (very rapid)

Amides -metabolized by liver (so, higher risk of liver toxicity with liver dysfunction)

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13
Q

What type of fiber would be most easily blocked?

A

a small myelinated fiber

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14
Q

What type of fiber would be most difficult to block?

A

a large unmyelinated fiber

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15
Q

Which type of fiber is hardest to block?

A

Type A - Alpha (proprioception, motor)

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16
Q

Which type of fiber is easiest to block?

A

Types B, C and Type A - delta (pain, temperature)

17
Q

Which would be blocked first a medium myelinated fiber or a small unmyelinated fiber?

A

the myelinated fiber

18
Q

A-alpha fiber

A
  • muscle proprioception
  • Largest fiber type
  • myelinated
19
Q

A-beta fiber

A
  • Second largest fiber
  • Touch
  • myelinated
20
Q

A-delta fiber

A
  • 3rd largest fiber
  • pain and temperature
  • myelinated
21
Q

C-nerve fiber

A
  • Not myelinated
  • pain, temperature, itch
  • Small fiber
22
Q

Sequence of nerves to be blocked

A
  1. Sympathetic
  2. Temperature
  3. Pain
  4. Light touch
  5. Motor
23
Q

Epidural block

A

-local anesthetic extradurally

24
Q

Caudal block

A

-epidural block in the caudal canal via the sacral hiatus

25
Spinal block
injection into cerebrospinal fluid in the subarachnoid space
26
Why is bupivacaine banned by the FDA in obstetrics for epidural anesthesia?
cardiotoxicity
27
How can you tell local anesthetics with and without epinephrine by the label on the bottle?
red label if it contains epi
28
Amides local anesthetics
Pharmacokinetics: hepatic metabolism - bupivacaine is most likely to cause heart problems - CNS effects (light headed, sedation, restlessness, nystagmus, tonic-clonic convulsions
29
Ester local anesthetics
Pharmacokinetics: rapid metabolism by plasma esterases - Metabolites can cause antibody formation ex. Benzocaine, cocaine, procaine, tetracaine
30
Prilocaine: ADE
can convert hemoglobin to methemoglobin
31
What medication is given to someone having a convulsion due to anesthetic toxicity?
Diazepam IV (Valium)