Local Anesthetics

Question 1

Local anesthetics produce tranisent loss of _____,_____,_____ ?

Answer 1

Sensory, Motor, Autonomic Function

Question 2

Local anesthetics produce a conduction block by preventing passage of _____ through selective channels in the nerve membrane?

Answer 2

Na+

Question 3

What is responsible for the speed of a local anesthetics onset?

Answer 3

PKa

Question 4

The unionized portion of the drug is _____ and is what actually gets into the cell

Answer 4

Lipophilic

Question 5

Once the lipophilic portion of the drug gets into the cell it redistributes into _____ and _____ based on the Ph inside the cell and the drugs PKa.

Answer 5

Ionized and Nonionized

Question 6

Most local anesthetics are _______ and range from _____ to ____ PKa?

Answer 6

Weak Bases

8.0-9.0

Question 7

Most drugs are weak bases but this drug we give in anesthesia is a weak acid?

Answer 7

Sodium Thiopental

Question 8

Answer 8

Base

Question 9

Answer 9

Acid

Question 10

Drug PKa is 8.2 and is injected IV in normal Patient with a PH of 7.4. Does the curve shift to the right or left and what portion increaes Ionized or nonionized?

Answer 10

Shifts to the Left

Increasing nonionized portion

Question 11

The primary active sight of a local anesthetic is where?

Answer 11

Intracellular

Question 12

Which part of the local anesthetic binds to the receptor site the anion or cation?

Answer 12

cation

The charged portion

Question 13

Potency correlates with what in the local anesthetic?

Answer 13

Lipid solubility therefore the nonionized portion

Question 14

Durration of action depends on what?

Answer 14

The amount of the drug protein bound to the channel not refering to protein binding intravascularly because the drug is in the cell at this point

Question 15

Which Local anesthetic is only used in its S enantiomer form?

Answer 15

Ropivacaine

Question 16

which local anesthetic is achiral?

Answer 16

Lidocaine

Question 17

Local anesthetics are either ______ or _____?

Answer 17

Esters or Amides

Question 18

Addition of Epi does 3 things what are they?

Answer 18

Prolong the Block

Increase intensity of the Block

Decrease systemic absorption of the LA

Question 19

Local anesthetics are composed of 3 parts ?

Answer 19

Lipophilic Group, Amide or Ester, Hydrophilic Group

Question 20

NO Question Just view it

Answer 20

NO Answer Just view it

Question 21

Amides are metabolized where?

Answer 21

Liver

Question 22

Esters are metabolized where?

Answer 22

Plasma Cholinesterase

Question 23

Ester or Amide

Answer 23

ESTER!!!!

Question 24

Ester or Amide

Answer 24

ESTER

Question 25

Ester or Amide

Answer 25

AMIDE

Question 26

Ester or Amide

Answer 26

AMIDE

Question 27

Amides are Metabolized 3 ways?

Answer 27

N-dealkylation, Amide Hydrolysis, Aromatic Hydroxylation

Question 28

List all Ester Local anesthetics?

Answer 28

Cocaine, Benzocaine, Procaine, Tetracaine, Chloroprocaine

Question 29

List local anesthetics that are common Amides

Answer 29

Lidocaine, Bupivacaine, Ropivacaine, Mepivacaine, Prilocaine,