LO 2 - Part 1 Flashcards
Describe the importance of collagen in tooth formation
- Calcified structures in the teeth – dentin, cementum and bone - depend on proper collagen deposition.
- Immediately after collagen formation, mineralization begins.
- Adequate nutrients are necessary during both collagen formation & mineral deposition in order to prevent structural imperfections.
Describe collagen
- Tough bundles of fibre
with great tensile strength - Collagen is a fibrous structural protein that is the main protein of connective tissue
- Is the main component of teeth and bone - 90-95% of bone matrix is made up of collagen
___________ is the deposition of inorganic materials (no carbon) on an organic matrix (protein & lipids)
Mineralization
Describe the importance of minerals in the body
- Minerals account for only 4% of total body weight but are essential to human health
- Minerals provide compression strength over the tensile strength of collagen
- Resembles reinforced concrete
How are minerals classified?
- Major (“Macro” Minerals) – body needs larger amounts > 100 mg/day – calcium, phosphorus, sodium, potassium, magnesium, chlorine, sulfur.
- Trace Elements (“Micro” Minerals) – body needs in smaller amounts <100 mg/day – iron, copper, zinc, manganese, iodine, fluorine, etc.
- 100 mg is dividing line between Macro and Micro Minerals
- Ultra-Trace Elements (Minerals) –No DRI - required, if at all, in minute amounts: boron, nickel, silicon, tin, aluminum, lead, lithium, & mercury
Describe where calcium is found in the body
- Calcium is the most abundant mineral in the human body
- More than 99% of total body calcium is stored in the bones and teeth where it functions to support their structure
- The remaining 1% is found throughout the body in blood, muscle, and the fluid between cells.
What is the ideal calcium-to-phosphorus ratio for adults required for proper mineralization of bone?
1:1
Phosphorous levels go ___________ calcium levels go ___________ –contributing to potential loss of bone mass.
up; down
How much calcium is required by adults? Children?
- Most adults require in the range of 1,000 mg/day (1,200 if over 50)
- For growing children aged 9 -18 1,300 mg/day
How is calcium absorbed?
- Calcium is principally absorbed in the small intestine
- Under normal conditions, less than 1/3 calcium consumed is absorbed – best absorbed in small amounts throughout the day
List some good sources of calcium
- Milk and Dairy products
- Salmon, Sardines, Oysters
- Almonds
- Seeds – poppy, sesame, chia
- Beans & legumes
- Dark Green leafy vegetables: spinach, all the Chinese cabbages: kale, bok choy, collard greens, broccoli
- Calcium & Vitamin D Fortified Beverages: soy, rice and almond beverages; orange juice
From which sources are calcium best absorbed?
Calcium from dairy is absorbed better than calcium from dark leafy vegetables because oxalates in vegetables (ex: spinach) bind the calcium and interfere with absorption
___________ is the excess levels of calcium in blood seen most frequently in infants 5-8 months old due to inappropriate use of vitamin D preparations (ie: supplements)
Hypercalcemia
What can hypocalcemia lead to?
Hypothyroidism as well as bone diseases
Describe osteoporosis
Refers to the degeneration of already constructed bone (brittle bones) seen in adults/seniors
Describe Osteomalacia (Rickets in children)
- Is an abnormality in the building process of bone (defective bone mineralization), making them soft - attributed to vitamin D deficiency
What are the oral consequences of calcium deficiency?
- During tooth formation deficiency could result in incomplete calcification of teeth, failure of dentin formation, delayed dentition; small molars
- After tooth eruption: deficiency could result in Weakened alveolar bone; The breakdown of healthy periodontal tissue (alveolar bone; cementum, gingiva); Increased risk of decay
What may calcium deficiency result from?
- Lack of education & false belief that adults do not require calcium
- The fact that it may be difficult to achieve required intake from diet alone
- Acidifying influences in the diet & insufficient vitamin D
- Lactose intolerance coupled with food allergies/aversions
Describe phosphorus in the body
- Phosphorous is the second most abundant mineral in the body
- It makes up 1% of a person’s total body weight.
- It is present in every cell of the body, but most – 85% - is found in the bones and teeth.
What is phosphorus needed for?
- The metabolism of macronutrients
- The composition of phospholipids
How much phosphorus do adults require? Where is it absorbed?
- Adults (over 18) 700mg/day
- Phosphorous is absorbed in the small intestine like calcium
List the food sources of phosphorus
- Primary sources include milk products and meats – it is also used widely as a food additive in baked goods, cheese, processed meats & soft drinks
- A diet adequate in calcium and protein will contain sufficient phosphorous
___________ may be seen in cases of persons with thyroid disease (hypo) or renal insufficiency – body is not able to clear excess
Hyperphosphatemia
___________ may result from long term ingestion of antacids which binds to phosphorous interfering with absorption
Hypophosphatemia
__________ can also result in phosphorous malabsorption deficiencies. Insufficient dietary sources may also be at play. Principal clinical symptom = muscle weakness.
Intestinal conditions (notably IBS)
During tooth formation deficiency of phosphorus could result in ___________
incomplete calcification of teeth, failure of dentin formation and increased susceptibility to caries.