Living Control Mechanisms Flashcards
Homeostasis
The maintenance of a constant internal environment in response to changing external conditions.
Temperature, blood-glucose, blood-oxygen.
Autocrine (communication)
Cells talking to themselves.
Signal produced goes back to the same cell.
Receptor on same cell.
Paracrine (communication)
Cells talking to neighboring cells a short distance away.
Signal diffuse across gap between 2 cells.
Does not enter bloodstream.
Endocrine (communication)
Cells talking to other cells elsewhere in the body.
Signal = hormone.
Travel in blood to reach more distant target.
Hormone
Molecule that acts as a chemical messenger and travels in the bloodstream.
Classified according to structure: amino acid derivative, peptide and steroid.
Amino acid derivative hormones
Synthesised from tyrosine. Very small. Quick response. Hydrophillic so can dissolve in blood. Adrenaline.
Peptide hormones
Made of amino acids.
Vary in size from few amino acids to small protein.
Quick response - signal transduction cascade.
Hydrophillic so can dissolve in blood.
Receptor is extracellular as hormone can’t move through hydrophobic tails of phospholipid bilayer.
Steroid hormones
All made from cholesterol.
Different enzymes modify cholesterol in different ways to produce a variety of hormones.
Slow response - affects DNA directly.
Lipid soluble.
Transported into blood bound to protein as can’t dissolve in water.
Receptor is intracellular as hormone is lipid soluble.
Simple feedback loop
1) Stimulus.
2) Sensor.
3) Control.
4) Effector.
5) Repeats.