Liver Problems Flashcards
What are the functions of the liver?
- Factory for producing essential proteins including albumin
- Produces clotting factors
- Essential role in absorption and metabolism of fats and other food stuffs
- Storage of glycogen, minerals and other substrates
- Metabolism and excretion of toxic products in the body
What is included in LFTs?
-Bilirubin (total and split)
-ALT/AST (alanine aminotransferase/aspartate aminotransferase)
-Alkaline phosphatase
Gamma glutamyl transferase (GGT)
When is ALT/AST elevated?
In hepatocellular damage (hepatitis)
When are alkaline phosphatase and GGT elevated?
Biliary disease
What tests are used to assess the function of the liver?
- Coagualtion (prothrombin time (PT)/INR, APTT)
- Albumin
- Bilirubin
- Blood glucose
- Ammonia
How can paediatric liver disease manifest?
- JAUNDICE
- Incidental finding of abnormal blood test
- Symptoms/signs of chronic liver disease
What are the signs of chronic liver disease in children?
- Encephalopathy
- Jaundice
- Epistaxis
- Cholestasis
- Ascites
- Hypotonia
- Peripheral neuropathy
- Rickets secondary to vit D deficiency
- Varices with portal hypertension
- Spider naevi
- Muscle wasting
- Bruising and petechiae
- Spleomegaly
- Hypersplenism
- Hepatorenal failure
- Liver palms
- Clubbing
- Loss of fat stores
- Growth failure
What is jaundice?
- Yellow discolouration of skin and tissues due to accumulation of bilirubin
- Usually most obvious in sclera
When is jaundice usually visible?
Total bilirubin >40-50umol/l
What is diagnosis of infant jaundice dependent on?
- Bilirubin metabolism
- Age
How is bilirubin metabolised?
- Post mature RBC broken down in the reticuloendothelial system to bilveridan
- Converted to unconjugated bilirubin
- Bound to albumin and conjugated in the liver
- Mixes with bile in gallbladder and enters small intestine
- Coverted to urobilinogen and excreted by the kidneys as urine or in faeces
What is the solubility of conjugated bilirubin?
- Water soluble
- Fat insoluble
What is the solubility of unconjugated bilirubin?
- Fat soluble
- Water insoluble
When does pre-hepatic jaundice occur?
Excess of unconjugated birlirubin
When does intrahepatic jaundice occur?
-Excess of conjugated and unconjugated bilirubin jaundice due to issue within the liver
When does post-hepatic jaundice occur?
Excess of conjugated bilirubin normally due obstruction
What is early neonatal jaundice?
- <24 hours old
- ALWAYS PATHOLOGICAL
What can cause early neonatal jaundice?
- Haemolysis
- Sepsis
What is intermediate neonatal jaundice?
Occurs between 24hours and 2 weeks of age
What can cause intermediate neonatal jaundice?
- Physiological
- Breast milk
- Sepsis
- Haemolysis
What is prolonged neonatal jaundice?
Occurs after 2 weeks of age
What can cause prolonged neonatal jaundice?
- Extrahepatic obstruction
- Neonatal hepatitis
- Hypothyroidism
- Breast milk
Why does physiological jaundice occur?
- Shorter RBC life span in infants (80-90 days)
- Relative polycythaemia
- Relative immaturity of liver function
What type of jaundice is physiological jaundice?
Unconjugated
When does physiological jaundice occur?
After the 1st day of life as it takes time for RBC to break down
Why does jaundice occur with breast fed babies?
- Exact reason for prolongation of jaundice in breastfed infants unclear
- Inhibition of UDP by progesterone metabolite?
- Increased enterohepatic circulation?
What type of jaundice is breast milk jaundice?
Unconjugated
How long can breast milk jaundice persist?
Up to 12 weeks from birth