Liver neoplastic

Question 1

What is the most common benign liver tumor?

Answer 1

Cavernous hemangiomas

Question 2

The risk for this liver neoplasm is increased 30-40 fold in users of oral contraceptives.

Answer 2

Hepatocellular adenoma

Question 3

Of the three molecular subtypes of hepatic adenoma, which subtype has a high risk for malignant transformation?

Answer 3

Beta-Catenin Activated Hepatocellular Adenoma
Remarks: Three molecular subtypes: 1. HNF1-alpha; 2. Beta-catenin activated; 3. Inflammatory with activating mutations in gp130 - JAK/STAT signaling

Question 4

Most common liver tumor of early childhood?

Answer 4

Hepatoblastoma

Remarks: Activation of WNT signaling pathway including APC gene

Question 5

What are the two most common early mutations in hepatocellular carcinoma?

Answer 5

Activation of BETA-CATENIN and inactivation of p53

Question 6

What is the most important primary pathway for emergence of HCC in viral hepatitis and alcoholic liver disease?

Answer 6

High-grade dysplastic nodules

Question 7

A special variant of HCC with characteristic “scirrhous” tumor with fibrous bands coursing through it.

Answer 7

Fibrolamellar carcinoma

Remarks: 85% occur under the age of 35 years old, without gender predilection.

Question 8

What is the most common malignancy in the liver?

Answer 8

Metastatic