LIVER LECTURE FINALS Flashcards
FRENCH WORD____which means Yellow
Jaune
Characterized by the juandice
Discoloration of the skin, eyes, mucous membrane, sclera
Normal level of bilirubin
0.2-1.0 mg/dl
This term used in the laboratory to refer to a serum or plasma with a yellowish discoloration due to bilirubin
Icterus
What is the major types of jaundice
Pre-hepatic
Post-hepatic
Hepatic
Excessive amount of bilirubin is presented to the liver due to excessive hemolysis
Pre-hepatic
Increased bilirubin 1
Unconjugated hyperbilirubinemia
Impaired bilirubin excretion from the biliary obstructive diseases gallstones and tumor
Elevated B2
Post hepatic
Impaired cellular uptake and conjugation or abnormal secretion by the liver cell
Hepatic jaundice
What is the two syndrome from the unconjugated hyperbilirubinemia
Gilbert syndrome
Crigler-najjar syndrome
What is the two conjugated syndrome in the hyperbilirubinemia
Rotor’s syndrome
Dubin- johnson syndrome
• benign autosomal recessive hereditary disorder
• Genetic mutation of UGT1A1
•Elevated B,
• May have no symptoms but with mild icterus
Gilbert syndrome
UGT1A1 meaning??
UDP GLUCURONOSYLTRANSFERASE FAMILY 1 MEMBER A1
• More serious than Gilbert syndrome
• Characterized by deficiency of the enzyme UDPGT
• Type 1
• Complete absence of UPGT
• Life expectancy P1yr
• Type 2
• Severe/partial deficiency of UDPGT
Crigler-najjar syndrome
• autosomal recessive disease which presents shortly after birth with an increase of conjugated bilirubin without elevation of liver enzymes
• Dubin-Johnson Syndrome
• autosomal recessive disease which presents shortly after birth with an increase of conjugated bilirubin without elevation of liver enzymes
(ALT, AST)
• Deficiency in canalicular multidrug resistance/ multispecific organic anionic transporter protein
(MDR2/MOAT)
• Defective excretion by the liver cell
Dubin-Johnson syndrome
