Liver Lab Values Flashcards
Billirubin
0.1 - 1.2 mg/dL
Indicates status of bile ducts
Aspartate Aminotransferase (AST/SGOT)
7 - 25 IU/L
High amounts in hepatocytes and heart
Alanine Aminotransferase (ALT/SGPT)
3 - 23 IU/L
High amounts in hepatocytes, less so in heart
** More specific to liver**
Alkaline Phosphatase
41 - 133 IU/L
More common in bile duct cells, but also in intestine, bone, kidney, placenta
High levels seen in bile duct obstruction
Gamma GLutamyltransferase (GGT)
< 60 IU/L
Mild increase in hepatocellular damage/EtOH abuse
High levels in bile duct damage
Albumin
3.4 - 4.7 G/dL
But also influenced by systemic/liver disease, nutrition, thyroid, drugs
** Has a long half-life. Show response to changes **
Prothrombin Time
~12 (10.5 - 12.1) seconds
Best indicator of synthetic function
Depends on clotting factors AND vit K
** Short half-life, more responsive to change in liver fxn **
Ammonia
10 - 80 mcg/dL
If elevated pt has impaired ability to convert ammonia –> urea
Associated w/ hepatic encephalopathy
Childs A
5-6 points
10 year survival 80-90%
Childs B
7-9 points
5 year survival 60-80%
Childs C
Greater than or equal to 10
2 year survival < 50%
What components are used in the model for end-stage liver disease (MELD)?
Creatinine
Bilirubin
INR
Does NOT predict quality of life
Labs in acute viral hepatitis?
Very high AST, ALT
(ALT>AST)
PT/INR & albumin are normal to start
Labs in chronic viral hepatitis?
AST, ALT, alk phos, bilirubin all mildly elavated
PT/INR increased (marked)
ALB decreased (marked)
Labs in alcoholic hepatitis?
AST>ALT
PT/INR elevated
ALB decreased
