Liver Function Tests

Question 1

What do Albumin and total protein assess for?

Answer 1

Nutritional Status
( low albumin: not eating well or systemic issue)

Question 2

AST and ALT reflect what?

Answer 2

Hepatocellular injury

Question 3

Alkaline Phosphatase

Answer 3

Reflects cholestasis and infiltrative liver disease
Reflect bile but not specific to GI tract
(Can give indication if bile is draining well or not)

Question 4

Total Bilirubin

Answer 4

Direct Bilirubin- Bile in pancrease
Indirect Bili- Bile bound in the blood
(Indicates bile duct issues)

Question 5

Γ Glutamly Transpeptidase (GGT)

Answer 5

Helps differentiated the source of Alk Phos
(Increased GGT= bile duct injury or liver)

Question 6

AFP (𝛼 fetoprotein)

Answer 6

Tumor marker utilized in dx of HCC (not specific to HCC)
Elevated= concern for cancer somewhere

Question 7

PT/INR

Answer 7

Coagulation issues (liver injury will affect this)

Question 8

Lactic Dehydrogenase (LDH)

Answer 8

Indicates ischemic liver injury

Question 9

Iron/ Ferretin

Answer 9

Hemoglobin synthesis

Question 10

𝛼-1 antitrypsin

Answer 10

Specific form of liver injury

Question 11

5’ nucleotides

Answer 11

Indicate parenchymal injury