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Ch. 4 - Hepatology > Liver Failure > Flashcards

Liver Failure Flashcards

1
Q
A
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2
Q

Define liver failure. Classify according to the time since symptom onset.

A
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3
Q

What is Cirrhosis?
Gold standard dx of cirrhosis?

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4
Q

Is cirrhosis and liver failure the same?

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5
Q

What are the causes of acute liver failure?

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6
Q

What are the causes of chronic liver failure?

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7
Q

What are the causes of acute and chronic liver failure?

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8
Q

List the RFs for liver failure

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9
Q

Describe the pathogenesis of cirrhosis.

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10
Q

Describe the pathogenesis of portal HTN.

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11
Q

List the ddx for liver failure

A

The causes are also ddx

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12
Q

List the symptoms/RFs you would like to ellict from a liver failure history.

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13
Q

How would you grade hepatic encephalopathy

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14
Q

Outline the exam findings you would expect in a liver failure case.

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15
Q

What are the diagnostic investigations for liver failure.

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16
Q

How would you assess for synthetic function of the liver?

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17
Q

Alcoholic hepatitis on LFT will show

A

What is the cause of a 2:1 ALT:AST?

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18
Q

What does the liver autoimmune screen test for?

A

Autoimmune hep - anti-LKM1, IgG4, ASMA
PBC - AMA

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19
Q

What is the tumour marker for HCC?

A

AFP

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20
Q

What is the use of an U/S liver in Liver failure?

A
21
Q

What is the use of a fibroscan in Liver failure? What imaging is it based on

A
22
Q

What is the ideal timeframe in which an ascitic tap should be performed in liver failure?
What information would the tap provide?

A
23
Q

What are the findings on liver biopsy in cirrhosis (4)

A
24
Q

What test can be to detect alcohol consumption within the last 30 days?

A
25
Q

What are the supportive investigations for liver failure?(justify)

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26
Q

What are ALL the investigations for liver failure?(justify)

A
27
Q

What is the use of the following classification systems:
1.Child-Pugh?
2. MELD?
3. Maddrey’s Discriminant Function for Alcoholic Hepatitis?
4. King’s College Criteria for Liver Transplant?

A

1.Child-Pugh - cirrhosis severity.
2. MELD - 3 month mortality of end-stage liver disease.
3. Maddrey’s Discriminant Function for Alcoholic Hepatitis - predicts prognosis and steroid benefit in alcoholic hepatitis.
4. King’s College Criteria for Liver Transplant - used to list patients for acute urgent liver transplant.

28
Q

How would you grade prognosis of end stage liver disease?

A
29
Q

Outline the grading system used to list patients for an acute liver transplant.

A
30
Q

Outline the grading system that predicts prognosis and steroid benefit in alcoholic hepatitis.

A
31
Q

In the setting of a paracetamol OD, when would you prescribe activated charcoal over NAC and vice versa. How are they given?

A
32
Q

High risk patients may develop toxicity to paracetamol at lower plasma levels. WHat are these high risk groups?

A
33
Q

Outline the management of acute liver failure secondary to paracetamol OD

A
34
Q

Describe to preventative measures to decrease risk of liver failure?

A
35
Q

How would you treat the symptoms of hepatic encephalopathy?

A

lactulose - prevention and treatment
Rifaximin - for recurrent encephalopathy

36
Q

How is a therapeutic abdominal paracentesis performed?

A
37
Q

What is the TIPSS procedure and what is its main risk?

A
38
Q

What is the definitive management for liver failure?

A

Transplant ttek

39
Q

Outline the pharmacological management for chronic liver failure.

A
40
Q

Outline the non-pharmacological management for chronic liver failure. Describe them.

A
41
Q

What are the S+S of decompensated liver disease?

A
42
Q

What are the S+S of hepatopulmonary syndrome?

A
43
Q

What is the treatment of SBP?

A
44
Q

What are the S+S of Wernicke’s Encephalopathy?

A
44
Q

How often in screening for HCC done in CLD patients? How is it done?

A
45
Q

What are the S+S of Korsakoff’s psychosis?

A
46
Q

Describe the possible complications of liver failure.

A
47
Q

Describe this image.

A
48
Q

Compare the prognosis of compensated vs decompensated liver failure.

A

Ch. 4 - Hepatology (8 decks)

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