Liver Disorders Flashcards
What is Biliary Atresia?
The obliteration of the intra and extra hepatic biliary tree
Presentation of Biliary Atresia?
Mild jaundice and pale stools
What do investigations for Biliary Atresia reveal?
Raised GGT and conjugated bilirubin
How is the Biliary Atresia diagnosis confirmed?
Cholangiogram
Treatment for Biliary Atresia?
Surgery, Liver transplant if surgery fails
Investigation of neonatal hepatitis syndrome?
Urine sample and galactose 1 phosphate test
Treatment for neonatal hepatitis syndrome?
Galactose free diet
Alagille Syndrome presentation?
Triangular face, wide spaced eyes, pruritis, faltering growth
Investigation of Alagille Syndrome?
Confirm faltering growth
Treatment of Alagille Syndrome?
Fat soluble vitamins
Progressive familial intrahepatic cholestasis presentation?
Rickets, jaundice, intense pruritis
Investigation for Progressive Familial Intrahepatic cholestasis?
Identify gene mutations
Treatment for Progressive Familial Intrahepatic cholestasis?
IBAT
What is progressive familial Intrahepatic cholestasis?
AR disorder that affects bile transport
Hepatitis A transmission?
Feco oral
How to diagnose Hepatitis A?
IgM antibody
What do we do with their close contacts
Vaccinate
How is Hepatitis B spread
Sexually, Horizontally, or through blood transfusions
Clinical signs of Hepatitis B?
Asymptomatic
Diagnosis of hepatitis B?
HBV antigens
Hepatitis C transmission?
Vertical, worsened if HIV too
Hepatitis C treatment?
Oral direct acting antivirals
What does Hepatitis D do?
Exacerbates HBV infection, depends on it for replication too
How is Hepatitis E transmitted?
Enterally
Hepatitis E presentation?
Mild self limiting illness
