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3 ALI > Liver Disease > Flashcards

Liver Disease Flashcards

0
Q

What stain shows iron deposition in the liver?

A

Perls stain

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1
Q

Mallory hyaline in the liver is associated with what?

A

Alcoholic liver disease

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2
Q

What stain stains copper associated protein- eg in Wilson disease?

A

Shikata

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3
Q

Hep A transmission

A

Faecal-oral

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4
Q

Hep B virus type

A

Enveloped dsDNA

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5
Q

Hep C incubation period

A

2-26 weeks

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6
Q

Hep D virus transmission

A

Parenteral

Close contact

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7
Q

Hep E virus type

A

Unenveloped ssRNA

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8
Q

Does hep D cause hepatitis?

A

Not on it’s own- it must work with Hep B

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9
Q

Cirrhosis increases the risk of developing…

A

Hepatocellular carcinoma

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10
Q

Chronic autoimmune hepatitis

A

Acute sudden onset
Affects young women
Autoantibodies - ASM & ANA most common

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11
Q

ANA

A

Anti nuclear antibodies

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12
Q

ASM

A

Anti smooth muscle antibodies

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13
Q

Is cirrhosis reversible?

A

No

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14
Q

Is steatosis reversible?

A

Yes- if patient stops drinking

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15
Q

Causes of NASH

Non alcoholic steato-hepatitis

A

Diabetes Mellitis
Drugs
Parenteral nutrition
Intestinal by-pass surgery

16
Q

What are the 2 types of hepatotoxins?

A

Intrinsic (eg paracetamol) - dose related

Idiosyncratic (eg autoimmunity) - metabolic

17
Q

Primary sclerosing cholangitis is associated with…

A

IBD (eg UC)

18
Q

Iron regulation

A

Hepcidin made by liver
Recirculates to enterocytes
Controls iron absorption from gut

Hemojuvilin- released from muscle- control Hepcidin
Hepatocyte transferrin receptor 2 also involved

I a so confused!!!!!!! Me too jemmies :o

19
Q

What is mutated in Wilson’s disease?

A

Chr 13 copper transporting ATPase

20
Q

What’s the most common cause of cirrhosis?

A

Alcoholic liver disease

21
Q

Consequences of cirrhosis

A

Impaired liver function:
Hypoalbuminaemia
Reduced synthesis of coagulation factors
Failure to detoxify

Portal hypertension:
Varices

Na & water retention: Ascites

22
Q

Most common liver tumour?

A

Metastatic

Hepatocellular carcinoma

23
Q

Marker for hepatocellular carcinoma

A

Alpha fetorprotein

3 ALI (3 decks)

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