Liver Disease Flashcards
What stain shows iron deposition in the liver?
Perls stain
Mallory hyaline in the liver is associated with what?
Alcoholic liver disease
What stain stains copper associated protein- eg in Wilson disease?
Shikata
Hep A transmission
Faecal-oral
Hep B virus type
Enveloped dsDNA
Hep C incubation period
2-26 weeks
Hep D virus transmission
Parenteral
Close contact
Hep E virus type
Unenveloped ssRNA
Does hep D cause hepatitis?
Not on it’s own- it must work with Hep B
Cirrhosis increases the risk of developing…
Hepatocellular carcinoma
Chronic autoimmune hepatitis
Acute sudden onset
Affects young women
Autoantibodies - ASM & ANA most common
ANA
Anti nuclear antibodies
ASM
Anti smooth muscle antibodies
Is cirrhosis reversible?
No
Is steatosis reversible?
Yes- if patient stops drinking
Causes of NASH
Non alcoholic steato-hepatitis
Diabetes Mellitis
Drugs
Parenteral nutrition
Intestinal by-pass surgery
What are the 2 types of hepatotoxins?
Intrinsic (eg paracetamol) - dose related
Idiosyncratic (eg autoimmunity) - metabolic
Primary sclerosing cholangitis is associated with…
IBD (eg UC)
Iron regulation
Hepcidin made by liver
Recirculates to enterocytes
Controls iron absorption from gut
Hemojuvilin- released from muscle- control Hepcidin
Hepatocyte transferrin receptor 2 also involved
I a so confused!!!!!!! Me too jemmies :o
What is mutated in Wilson’s disease?
Chr 13 copper transporting ATPase
What’s the most common cause of cirrhosis?
Alcoholic liver disease
Consequences of cirrhosis
Impaired liver function:
Hypoalbuminaemia
Reduced synthesis of coagulation factors
Failure to detoxify
Portal hypertension:
Varices
Na & water retention: Ascites
Most common liver tumour?
Metastatic
Hepatocellular carcinoma
Marker for hepatocellular carcinoma
Alpha fetorprotein
