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3 ALI > Clinical Biochemisty Of Liver Disease > Flashcards

Clinical Biochemisty Of Liver Disease Flashcards

0
Q

High ALT?

ALT&raquo_space; ALP

A

Hepatocellular cause

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1
Q

ALT

A

Alanine aminotransferase

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2
Q

High ALP?

ALP&raquo_space; ALT

A

Blockage

Cholestatic cause

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3
Q

Functions of the liver

A

Carb metabolism - gluconeogenesis, glycogen syn & breakdown

Fat met - FA syn, chol syn & exc, lipoprotein syn, ketogenesis, bile syn

Protein met - syn plasma proteins, urea syn

Hormone met

Storage - glycogen, vit A, vit B12, iron

Met & exc of drugs

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4
Q

Haem -> bilverdin

A

Haem oxygenase

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5
Q

Bilverdin –> uncondugated bilirubin

A

Biliverdin reductase

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6
Q

Total bilirubin

A

Conjugated & uncondugated

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7
Q

Direct bilirubin

A

Conjugated bilirubin

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8
Q

Indirect bilirubin

A

Uncondugated bilirubin

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9
Q

In what form is the majority of bilirubin in the blood?

A

Uncondugated

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10
Q

What makes urine dark in a jaundiced patient?

A

Bilirubin

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11
Q

Pre hepatic

A

Haemolysis

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12
Q

Hepatic

A

Hep
Cirrhosis
Tumours
Inborn errors

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13
Q

Post hep

A

Gallstones

Carcinoma

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14
Q

Half life of albumin

A

20 days (goes down in chronic)

BUT

also goes done in infection & inflammation- liver makes pro inflammatory molecules instead of albumin

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15
Q

Pro thrombin time

A

Good indicator of liver function

16
Q

Tests that reflect liver function

A

Bilirubin
Albumin

PT time
Urea
Glucose

17
Q

Test that reflect liver damage

A

ALK Phos
ALT

GGT
AST

18
Q

A1-anti-trypsin deficiency

A

Genetic disorder
Causes defective production of A1AT
Leading to decreased A1AT activity in the blood and lungs,
and deposition of excessive abnormal A1AT protein in liver cells.

19
Q

Finding out cause of acute hepatitis, request:

A

Serology
Alcohol, paracetamol
Liver autoantibodies (SMA, AMA)
(Ferritin)

20
Q

When evaluating consequences of acute hepatitis, request:

A 
PT time
Glucose
Direct & indirect bilirubin
Platelets 
(Ammonia)

3 ALI (3 decks)

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