Liver and Jaundice Flashcards

1
Q

What is jaundice?

A

Yellowing of the skin and sclera due to high levels of serum bilirubin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

When is jaundice considered…

a) Pathological?
b) Physiological?

A

a) Jaundice which presents in the first 24 hours of life OR after 2 weeks (3 weeks in prem babies)
b) Jaundice which presents after 24 hours and resolves before 2 weeks (typically resolves by 7-10 days)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Give some causes of:

a) Jaundice within the first 24 hours of life
b) Prolonged jaundice (after 2 weeks)

A

a) TORCH infections; haemolytic disease of the newborn (e.g. Rh/ABO incompatibility); hereditary spherocytosis; G6PD deficiency
b) Biliary atresia; infections e.g. UTI; metabolic disorders e.g. Gilbert’s, Crigler-Najjar; endocrine disorders, e.g. congenital hypothyroidism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

If a mother is identified as rhesus negative, what treatment is given to prevent haemolytic disease of the newborn?

A
  • Anti-D injections
  • 1st injection given at 28 weeks
  • 2nd injection given at 34 weeks
  • Further injection given at birth (plus after any sensitising event)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Describe the investigation of haemolytic disease of the newborn

A

Bloods:

Haemolytic anaemia:

  • Raised reticulocyte count
  • Raised unconjugated bilirubin

Specific tests:

  • Positive direct Coombs test (antibody-mediated anaemia)
  • Kleihauer test can be done to assess how much foetal blood has mixed with maternal blood (so that adequate amount of anti-D can be given to the mother)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Describe the pathophysiology of biliary atresia

A

Congenital disorder in which one or more bile ducts are abnormally narrow, blocked or absent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the clinical features of biliary atresia?

A
  • Jaundice (prolonged)
  • Pale stools, dark urine
  • Hepatomegaly
  • Faltering growth
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are the benign causes of neonatal jaundice?

A
  • Physiological jaundice

- Breast milk jaundice (breastfed babies are usually more jaundiced than bottle-fed babies)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Which factors contribute to physiological jaundice?

A
  • Increased RBC breakdown

- Hepatic immaturity/inefficient bilirubin metabolism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

How is jaundice measured?

A

1) Examination: check the skin and sclerae - is the baby clinically jaundiced?
2) Transcutaneous bilirubin meter
3) Serum bilirubin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Describe the management of neonatal jaundice

A
  • Serum bilirubin level is used to determine threshold for intervention (NICE guidelines)
  • 1st line = phototherapy
  • 2nd line = exchange transfusion
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Describe the pathophysiology of kernicterus

A

Encephalopathy resulting from deposition of unconjugated bilirubin in the basal ganglia and brainstem

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are the complications of kernicterus?

A
  • Seizure
  • Coma
  • Intellectual disability
  • Cerebral palsy
  • Death
How well did you know this?
1
Not at all
2
3
4
5
Perfectly