Liver Flashcards
best test for vit k def and warfarin therapy
PT
Useful in determining liver faulure; shortest half life
Factor VIII
AST: ALT ratio
> 2:1
more specific for liver disease
ALT
Elevations point to extrahepatic causes
obstructive cholestasis
direct (conjugated bilirubin)
elevations point to intrahepatic cholestasis; hemolytic d/o
indirect (unconjugated bilirubin)
indicative of biliary obstruction
ALP
early marker and sensitive test for hepatobiliary disease
GGTP
JAUNDICE IS DETECTABLE WHEN SERUM BILIRUBIN IS MORE THAN ___
2.5-3 mg/dL
central arteriole with tiny radiating vessels, mainly on trunk and face
spider angiomata
cause of spider angiomata
elevated estradiol
decreased estradiol degradation in the liver
prominent veins radiating from umbilicus
caput medusae
epigastric vascular murmur
cruveilhier- Baumgarten syndrome
erythema sparing central portions of the palm
palmar erythema
cause of palmar erythema
inc estradiol
dec estradiol degradation in the liver
sweet pungent smell n liver failure
fetor hepaticus
spontaneous bacterial peritonitis
neutrophil count more than ___
250/ml
culture positive community acquired SBP
e. coli
culture positive nosocomial SBP
strep enterococcus
tx SBP
1ST line- cefotaxime
co- amox, quinolones
predicts the surgical risk of intra abdominal operations performed in px wth cirrhosis
child-turcotte-pugh score
normal portal pressure
5-10 mmhg
direct portal venous pressure >5mmhg of IVC pressure
splenic pressure more than 15
portal htn
pressure necessary for varices to form and bleed
> 12mmhg
most accurate method of determining portal htn
hepatic venography
most significant manifestation of portal htn
esophageal varices ( left gastric vein)
mngt of acute esophageal variceal bleeding
vasopressin
octreotide- preferred
end to side porta caval shunt
eck fistula
large diameter interposition shunt
mesocaval; drapanas
proximal splenorenal shunt
Linton
total diversion of blood from PV to VC
NON SELECTIVE
partial diversion of blood from PV to VC
selective
for unsuitable for shunt procedures:
transection of esophagus, splenectomy, truncal vagotomy and pyloroplasty
ligation of venous branches of distal esophagus and the proximal stomach from the level of the inferior pulmonary vein
sugiura-fukugawa procedure
consists of:
splenectomy
perihiatal devascularization of the lower esophagus
ligation of left gastric vessels
devascularization of the proximal half of the stomach
separation of stomach from its bed
Hassab procedure
congestive hepatopathy characterized by obstruction to hepatic venous outflow
Budd-Chiari syndrome
affects YOUNG WOMEN with MYELOFIBROSIS
Factor V Leiden mutation
anti cardiolipin antibodies
hypermomocysteinemia
Budd-Chiari syndrome
tx Budd-Chiari syndrome
systemic anti coagulation
DX Budd-Chiari syndrome
INITIAL: abd UTZ
Definitive: hepatic venography
MC route of hepatic exposure to bacteria
Ascending- biliary tree
which lobe is more commonly affected in pyogenic liver dse
Right lobe
mc gram neg organism in pyogenc liver abscess
E. Coli
causative agent amebic liver abscess
Entamoeba histolytica
infective stage of E. histolytica
cyst
pathogenic stage of E. histolytica
trophozoite
usual location of amebic liver disease
superior-anterior aspect of right lobe
mildly elevated Alkaline phosphatase
(+)fluorescent antibody test
AMEBIC LIVER ABSCESS
Caused by echinococcus granulosus
hydatid disease
MOT: ova containing feces (dog)
hydatid disease
ova- intestines
adult cyst- liver
dx for hydatid disease
ELISA for echinococcal antigens
well defined lesion with ring-like calcifications
hydatid disease
sx tx hydatid disease
complete cyst removal with instillation of scolicidal agent
med tx hydatid disease
Albendazole
most frequently encountered liver lesion overall
hepatic cyst
tx of heaptic cyst
asymptomatic- observe
symptomatic: percutaneous aspiration and sclerotherapy
most common benign solid masses in the liver
hemangioma
tx of hemangioma
enucleation
asymmetrical peripheral enhancement with progressive centripetal enhancement
hemangioma
benign solid liver mass
assoc with women using OCP
Adenoma
benign liver mass with spontaneous rupture and hemorrhage and malignant degeneration
adenoma
benign liver mass usually DO NOT spontaneously rupture and hemorrhage and malignant degeneration
focal nodular hyperplasia
nuclear scan- cold
adenoma
nuclear scan- hot
focal nodular hyperplasia
metastatic liver tumors usally are from__
colon
mc malignant liver tumor
metastatic
criteria for liver transplant
MILAN
Tumor in the bifurcation of right hepatic duct
Klatskin tumor