liver Flashcards

1
Q

hepatic portal vein

A
  • a high conc of digested food products
  • from interestines
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2
Q

hepatic artery

A

oxygenated blood
from aorta

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3
Q

hepatic vein

A

blood leaves liver to vena cava
deoxygenenated blood

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4
Q

what is the name of cells of liver called

A

hepatocytes

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5
Q

what is the liver made of

A

several lobes

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6
Q

what does hepatocytes consist of

A
  • microvilli
  • golgi apparantus
  • RER
  • glycogen
  • mitrochondria
  • plasma memberane
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7
Q

what is kupffer cells

A
  • attached to sinusiods
    it break down harmful
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8
Q

increase in blood glucose

A
  • detects beta cells
  • insulin is secreated and attatch to target surface
  • incrase in permbility of target cell to glucose
  • activities enzyme that converts
    glucose to glycogen
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9
Q

decrease in bloood glucose

A
  • detects alpha cells
  • secrete glucagon
  • attach to receptor
    so glycogen to glucose
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10
Q

type 1 diabetes

A

no insulin

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11
Q

type 2 diabetes

A

fewer insulin receptor and less sensitivite response to insulin

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12
Q

transmination - protein metabolism

A

transferred to keto acids and new amino acids is produce

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13
Q

essential amino acids

A

come from diet

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14
Q

non-essential amino acids

A

made in the body

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15
Q

what is biliverdin

A

irons from heam metabolism is a green pigments

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16
Q

billirbin

A

is a yellow component of bile

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17
Q

transferrin

A

iron can combin to plasma membrane to be re-used

18
Q

what does lipoprotein contains

A
  • troglycerol
  • cholesterol
  • phospholipids
  • apolipoprotein
19
Q

what is a lipoloprotein

A

-chylomicrons
- VLDL
- LDL
- HDL

20
Q

Ethanol metabolisms

A

ethonal to acetaldehyde by ADH
acetaldehdye to acetate by ALDH

21
Q

ADH

A

Alcohol dehydrogenase

22
Q

ALDH

A

aldehyde dehydroganase

23
Q

symptoms of alochol liver disease

A

feeling sick
weight loss
yellow eyes and skin
vomiting blood
confusion and drowsiness

24
Q

alcohol hepatitis influnced by

A
  • genetic factors
  • liver disorder
    malunutrient
    concurrent consumption of food
25
Q

what is hepatitis

A

is an inflammation of liver condition

26
Q

what is a cirrhosis

A

is a scarring of the liver

27
Q

what enzyme is contained in the hepatocytes that is associate with drug metabolism

A

cytochrome P450 group

28
Q

drug metabolism phase 1 and 2

A

phase1 -
oxidation by the enzyme cytochrome pa450
phase 2-
conjugation
attach to ionise group
occurs in the cytoplasm of heptocyte

29
Q

describe how the drugs is metaoblisme by the liver

A
  • cytochrome P450 enzyme
  • phase 1 oxidation
  • drug may be extracted it water soluable
  • phase 2 conjugation
  • addition of an ionised group making it more soluable
  • exatracted in bile and urine
30
Q

vitamin E

A

fat -Soluble antioxidant

31
Q

vitamin C

A

water soluble antitoxidant

32
Q

beta- carotene

A
  • precursor to vitamin A
33
Q

phosphorus

A
  • nucleic acids
  • muscle dysfunction and weakness
34
Q

potassium

A

-nervous conductance
- muscle weakness

35
Q

sodium

A
  • nervous conductnace
  • Na+ homeostasis
36
Q

Mg

A

bone and tooth structure

37
Q

Ca

A

bone and tooth structure

38
Q

manganese

A

bone development

39
Q

iron

A

heam group in heamgloin and mylogloin
anaemia

40
Q

flourine

A

component of tooth and bone

41
Q

flourine

A

component of tooth and bone