Lipoproteins and Apolipoproteins

Question 1

Which apolipoprotein is the surrogate marker for HDL?

a) Apo A-I
b) Apo A-II
c) Apo C
d) Apo E

Answer 1

a) Apo A-I

Question 2

It is the major apolipoprotein in VLDL

a) Apo B-48
b) Apo C
c) Apo B-100
d) Apo E

Answer 2

c) Apo B-100

Question 3

In electrophoretic mobility, where does VLDL migrates?

a) Origin
b) Pre-beta
c) Beta
d) Alpha

Answer 3

b) Pre-beta

Question 4

It is the smallest lipoproteins but the most dense

a) LDL
b) Chylomicrons
c) HDL
d) VLDL

Answer 4

c) HDL

Question 5

Cardioprotective lipoprotein

a) LDL
b) HDL
c) VLDL
d) IDL

Answer 5

b) HDL

Question 6

It functions as LPL cofactor for chylomicrons, VLDL, and HDL:

a) Apo C-I
b) Apo C-II
c) Apo C-III
d) All of the choices

Answer 6

b) Apo C-II

Question 7

In electrophoretic mobility, which lipoproteins migrate in the beta region?

a) VLDL
b) LDL
c) IDL
d) HDL

Answer 7

b) LDL

Question 8

Among the lipoproteins, which has the most triglyceride content?

a) VLDL
b) CM
c) HDL
d) LDL

Answer 8

b) CM or Chylomicrons

Question 9

Major apolipoprotein of chylomicron

a) Apo A-I
b) Apo A-II
c) Apo B-48
d) Apo B-100

Answer 9

c) Apo B-48

Question 10

Major apolipoprotein of LDL

a) Apo A-I
b) Apo A-II
c) Apo B-48
d) Apo B-100

Answer 10

d) Apo B-100

Question 11

It maintains the equilibrium of cholesterol from tissue back to the liver for bile synthesis

a) HDL
b) LDL
c) VLDL
d) IDL

Answer 11

a) HDL

Question 12

Also called as Floating Beta-lipoprotein:

a) IDL
b) Lpx
c) B-VLDL
d) Lp(a)

Answer 12

c) B-VLDL

Question 13

Also called as Sinking Pre-Beta-lipoprotein:

a) IDL
b) Lpx
c) B-VLDL
d) Lp(a)

Answer 13

d) Lp(a)

Question 14

It is associated with obstructive biliary disease and LCAT deficiency

a) IDL
b) Lpx
c) B-VLDL
d) Lp(a)

Answer 14

b) Lpx

Question 15

Mutation in the ABCA1 gene in chromosome 9 is indicative of:

a) Abetalipoproteinemia
b) Hypobetalipoproteinemia
c) Hypoalphalipoproteinemia
d) Tangier disease

Answer 15

d) Tangier disease

Question 16

Which type of hyperlipoproteinemia has a clinical laboratory findings of increase LDL, total cholesterol, triglyceride?

a) Type 1
b) Type 2a
c) Type 2b
d) Type 4

Answer 16

c) Type 2b

Question 17

LPL deficiency with clinical presentation of eruptive xanthoma and acute pancreatitis is indicative of

a) Mixed hyperlipidemia
b) Familial dysbetalipoproteinemia
c) Familial chylomicronemia
d) Primary hypertriglyceridemia

Answer 17

c) Familial chylomicronemia

Question 18

A mutation of MTTP gene with absolute nonexistent levels of apo B-48 and apo B-100 is indicative of

a) Abetalipoproteinemia
b) Bassen-Kornweig Syndrome
c) Either
d) Neither

Answer 18

c) Either

Abetalipoproteinemia is also known as Bassen-Kornweig Syndrome

Question 19

What is the reagent used in saponification to hydrolyze cholesterol esters?

a) Digitonin
b) Acetic anhydride
c) Ferric
d) Alcohol KOH

Answer 19

d) Alcohol KOH

Question 20

In Liebermann-Burchardt method, what would be the expected end product and its end color?

a) cholestadienyl monosulfonic acid - red
b) cholestadienyl monosulfonic acid - green
c) cholestadienyl disulfonic acid - red
d) cholestadienyl disulfonic acid - green

Answer 20

b) cholestadienyl monosulfonic acid - green

Question 21

In Salkowski method, what would be the expected end product and its end color?

a) cholestadienyl monosulfonic acid - red
b) cholestadienyl monosulfonic acid - green
c) cholestadienyl disulfonic acid - red
d) cholestadienyl disulfonic acid - green

Answer 21

c) cholestadienyl disulfonic acid - red