Lipoproteins Flashcards
How are long chained fatty acids transported in blood?
bound to ALB
What is the source of most circulating FFA?
mostly long chained fatty acids from hydrolysis of TG in adipocytes
How to medium chained fatty acids exist in blood?
bound to ALB or free
How to short chained fatty acids exist in blood?
free
What is the main source of short chained fatty acids?
mostly from fermentation by colonic or rumen bacteria
Why do free fatty acids in blood have low circulating concentrations/short half lives?
because, in health, there is rapid uptake by target tissues to use for energy
When would you find high levels of FFA? decreased?
increased: starvation/fasting
decreased: post prandial
how many FFA can ALB carry at one time?
7
What are the main target organs of FFA?
liver, kidney, heart, skeletal muscle
Describe FFA uptake at tissues
-enter cells via fatty acid transporters
-once inside, bound to cystolic fatty acid binding proteins
What are the two potential fates of free fatty acids once inside target tissue cells?
-oxidation to produce energy or to synthesize ketone bodies from resulting acetyl CoA
-re-esterification to TG for storage
What are the 4 main molecules transported by lipoproteins?
-TG
-Phospholipids
-cholesterol
-cholesterol esters
What are the 4 main lipoproteins?
-CM
-VLDL
-LDL
-HDL
What is an apolipoprotein?
it is the protein component of lipoproteins
What is the difference between peripheral and integral apolipoproteins?
peripheral: can be exchanged between lipoproteins
integral: can not be exchanged, it helps define the lipoprotein
What are the two integral apolipoproteins?
A and B
What are the two apolipoprotein B isoforms? describe their function
B48: synthesized in the intestine and specific to CM
B100: synthesized in the liver, component of lipoproteins originating in the liver, VLDL IDL LDL
What are the two A apolipoprotein isoforms? what lipoprotein are they integral to?
ApoA-1 is integral to HDL
ApoA-s are peripheral for CM