Lipids Flashcards

1
Q

predominant FA in coconut oil

A

lauric acid (12:0)

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2
Q

end product of mammalian FA synthesis

A

palmitic acid (16:0)

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3
Q

predominant FA in olive oli

A

18:1 (9)

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4
Q

Essential FAs

A
linoleic acid (18:2) -9,12
linolenic acid (18:3) -9,12,15
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5
Q

precursor of PG from linoleic acid

A

arachidonic (20:4)

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6
Q

arachidonic acid derived from

A

linoleic acid

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7
Q

RLS of lipogenesis

A

acetyl coA → malonyl coA

acetyl coA carboxylase

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8
Q

RLS of beta oxidation

A

traslocation of FA from cytosol to mitochondria

carnitine palmitoyl transferase

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9
Q

Net ATP yield of palmitate

A

106 ATPs

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10
Q

MC inborn error of FA oxidation

A

Medium chain FA DH def

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11
Q

peripheral neuropathy with ataxia, retinitis pigmentosa, abn in skin and bones
inc phytanic acid

A

Refsum dse

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12
Q

cerebrohepatorenal syndrome
inc VLCFA
liver dysfunction, mental retardation, weakness, hypotonia , craniofacial dysmorphism

A

Zellweger syndrome

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13
Q

inc VLCFA

neurodegeneration, adrenocortical insuff, hypogonadism

A

Adrenoleukodystrophy

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14
Q

products of ketogenesis

A

acetoacetate
B-hydroxybutarate
acetone

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15
Q

RLS of ketogenesis

A

acetoacetyl coA + acetyl coA → HMG coA reductase

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16
Q

why is liver not able able to use ketone bodies

A

lacks the enzyme succinyl coA-acetoacetate-coA transferase

17
Q

cofactor of LCAT found in HDL

A

Apo A1

18
Q

mediates assembly and secretion of VLDL

structural protein of VLDL, IDL

A

Apo B 100

19
Q

main apoprotein and mediates secretion of chylomicrons from small intestines

A

chylomicrons

20
Q

cofactor of lipoprotein lipase

A

apo C II

21
Q

mediates uptake of chylomicron remnants and IDLs

A

Apo E

22
Q

type I hyperlipoproteinemia

A

familial LPL def

23
Q

type IIa hyperlipoproteinemia

A

familial hypercholesterolemia

defective LDL receptor

24
Q

type III hyperlipoproteinemia

A

familial dysbetalipoproteinemia

abnormal apoE

25
Q

type IV hyperlipoproteinemia

A

familial hypertriacylglycerolemia

VLDL overproduction

26
Q

high TAG due to absence of apo CII leading to inactive LPL
aterosclerosis in elderly

d/t low or near absence of HDL

A

familial a-lipoprotein deficiency

Tangier dse
Fish eye dse
Apo A1-deficiencies