Lipids Flashcards
predominant FA in coconut oil
lauric acid (12:0)
end product of mammalian FA synthesis
palmitic acid (16:0)
predominant FA in olive oli
18:1 (9)
Essential FAs
linoleic acid (18:2) -9,12 linolenic acid (18:3) -9,12,15
precursor of PG from linoleic acid
arachidonic (20:4)
arachidonic acid derived from
linoleic acid
RLS of lipogenesis
acetyl coA → malonyl coA
acetyl coA carboxylase
RLS of beta oxidation
traslocation of FA from cytosol to mitochondria
carnitine palmitoyl transferase
Net ATP yield of palmitate
106 ATPs
MC inborn error of FA oxidation
Medium chain FA DH def
peripheral neuropathy with ataxia, retinitis pigmentosa, abn in skin and bones
inc phytanic acid
Refsum dse
cerebrohepatorenal syndrome
inc VLCFA
liver dysfunction, mental retardation, weakness, hypotonia , craniofacial dysmorphism
Zellweger syndrome
inc VLCFA
neurodegeneration, adrenocortical insuff, hypogonadism
Adrenoleukodystrophy
products of ketogenesis
acetoacetate
B-hydroxybutarate
acetone
RLS of ketogenesis
acetoacetyl coA + acetyl coA → HMG coA reductase