Lipids 3: Brown fat

Question 1

What is general structural features of white adipocytes vs brown adipocytes

Answer 1

White: contains single lipid droplet with peripheral nucleus and low mitochondria density.
Brown: Numerous small lipid droplets an

Question 2

What is location and function of white adipose vs brown adipose

Answer 2

White: Energy storage, receptors for hormones. pro inflammatory
Brown: metabolically active. Heats the blood and, thermogenesis

Question 3

What is Shivering thermogenesis

Answer 3

This is the

Question 4

What activates

Answer 4

Norepinehrine

Question 5

What

Answer 5

Each cell of brown adipose is highly specialised

Question 6

How does brown adipose getting tissue activated

Answer 6

1. Cold/ diet signals activates SympNS which releases noradrenaline which stimulates B-3 adrenoreceptor.
2. This makes Adenylate cyclase increase cAMP which activates protein kinase A.
3. PKA which phosphorylates
   a) CREB-> increased production of UCP 1 protein
   b) Perilipin -> exposes the TAG
   c) HSL-> hydrolyses the fatty acids from TAG.
4. Fatty acids go to the mitochondria to be oxidised
5. They make FADh