Lipid Synthesis Flashcards
Citrate is driven toward Fatty Acid synthesis under what conditions?
During conditions of excess energy like a high NADH/NAD ratio.
Fatty acid [B-oxidation/synthesis] happens in mitochondria and fatty acid [B-oxidation/synthesis] happens in the cytosol
B-oxidation; synthesis
What is the key regulatory step in fatty acid synthesis?
Acetyl CoA Carboxylase Reaction (uses biotin)
Malonyl CoA inhibits what B-oxidation enzyme?
CPT-I (Don’t want oxidation while synthesizing FA)
Order these reactions for fatty acid synthesis, starting with the first: reduction bond formation dehydration reduction
- ) Bond formation
- ) reduction
- ) dehydration
- ) reduction
What is the main product of FAS
Palmitate.
How can palmitate be further processed?
It can be elongated or unsaturated (if 9 C’s away from omega end.
What is VLDL made from and what happens to it once in the blood?
It’s created from TG and FACoA and other lipids (all in the liver). Once in the blood, LPL cleave of FA for E in muscles cells and storage in adipose tissue.
Glycerol 3-P requires what two enzymes for its formation?
Glycerol kinase (in liver) and glycerol 3-P DH (in adipose and liver).
List the steps for TG synthesis of connecting the FA to the glycerol.
- ) 2 palmitoyl CoA add to glycerol 3-P to form phosphatidic acid (loses to CoASH)
- ) Lose a P to form diacyglycerol and add one more palmitoyl CoA
What type of lipids constitute lung surfactant?
Glycerophospholipids
Cardiolipan is a larger molecule, that’s what gives it it’s rigidity (T/F)
T
Glycolipids (cerebrosides and gangliosides) have little issue with production, but degradation is much tougher. Aggregation leads to Tay-Sachs.
T
What role does dipalmitoylphosphatidylcholine play?
Most abundant lung surfactant.
If you have elevated carnitine molecules suggests that FA is not getting into cell but you’re burning those FAs
F
