Lipid Lowering Flashcards
cholestyramine
MOA: Bile acid sequestration
Indications: hyperlipidemia; pruritus; steatorrhea
P’dynamics:
P’kinetics:
Tox: constipation, increased triglycerides
Interactions: digitalis, inhibits lipid soluble drug absorption
considerations: Pregnancy C
Nicotinic acid
MOA: Vitamin
Indications: cholesterol reduction
P’dynamics: precursor to NAD; inhibits cAMP production
P’kinetics: T1/2=20-45m
Tox: facial flushing; contrindicated w/ acute liver disease
Interactions:
considerations: Pregnancy D
gemfibrozil
MOA: peroxisome proliferator-activated receptor alpha agonist (PPARA agonist)
Indications: triglyceride reduction
P’dynamics: Fibric acid derivative
PK: hepatic CYP3A4; F~100%; T.5=1.5h; renal excretion
Tox: GI distress, msk pain, hypoK,
Interactions: potentiates warfarin/indanedione; muscle cramps/rhabdo w/ statins.
considerations: Pregnancy C
clofibrate
MOA: peroxisome proliferator-activated receptor alpha agonist (PPARA agonist)
Indications: triglyceride reduction
P’dynamics: Fibric acid derivative
PK: hepatic CYP3A4; F~100%; T.5=1.5h; renal excretion
Tox: GI distress, msk pain, hypoK,
Interactions: potentiates warfarin/indanedione; muscle cramps/rhabdo w/ statins.
considerations: Pregnancy C
lovastatin
MOA: Statin: MHG-coA reductase inhibitor Indications: P'dynamics: P'kinetics: hepatic (CYP3a) T.5=2-5h; fecal excretion Tox: msk pain, abd pain, allergic sx. Interactions: grapefruit juice considerations: Pregnancy X
atorvastatin
sMOA: Statin: MHG-coA reductase inhibitor
Indications:
P’dynamics:
P’kinetics: hepatic (CYP3a) T.5=2-5h; fecal excretion
Tox: msk pain, abd pain, allergic sx.
Interactions: grapefruit juice
considerations: Pregnancy X
ezetimibe
MOA: cholesterol absorption inhibitor Indications: cholesterol reduction P'dynamics: NPC1L1 inhibitor in GI tract P'kinetics: F~35-65%; intestinal wall/hepatic; T1/2 =19-30h; fecal excretion Tox: headache, steatorrhea, Interactions: considerations: Pregnancy C
