Lipid Lowering

Question 1

What is the first-choice drug when choosing lipid lowering drugs?

Answer 1

Statins

Question 2

What is a….

good lipoprotein

bad lipoprotein?

Answer 2

HDL

LDL

Question 3

Statins are used a first line Tx for ….

Answer 3

hypercholesterolemia

Question 4

Statins reduce the risk of a vascular even in patients with _______ and ______ disease

Answer 4

diabetes and cardiovascular disease

Question 5

people with homozygous familial hypercholeserolemia show little response to Statin because of the dysfuction of…..

Answer 5

alleles of LDL receptors

Question 6

What are 3 adverse effecs of using Statins?

Answer 6

Myopathy

Rhabdomyolysis

Hepatotoxicity

Question 7

What two things incease the risk of myopathy?

Answer 7

if taken with Fibrates

and

with drugs that are metabolized with CYP450 - CYP3A4

Question 8

what kind of ppl should statins no be used?

Answer 8

pregnant or lactating women

Question 9

the reduction of bile acid synthesis increases __________

This means that it is not beneficial in patients with

Answer 9

hepatic TG synthesis

significant Hypertriglyceridemia

Question 10

Bile Acid Binding Resinns should be used with _______ to decrease LDL

Answer 10

statins

Question 11

Whats an important adverse effect of Bile acid resins?

Answer 11

they can prevent the absorption of other drugs

Question 12

Ezetimibe inhibits ________ absorption in the ________ by binding to the _________