Antiarrhythmic Drugs

Question 1

What 3 types of drugs are responsible for causing TdP?

Answer 1

Class Ia

Class III, but not Amiodarone

CYP inhibitors

Question 2

Is Tdp induced by EADs or DADs?

Answer 2

EADs

Question 3

If you take a Class 1a drug with a CYP inhibitor, why would it cause TdP?

Answer 3

This is because CYP inhibitors create less enzymes that are supposed to break down the antiarththymic drug and this drug will then be around longer

Question 4

DADs are caused by

Answer 4

digoxin/catecholamines, or by hypercalcemia

Question 5

DADs or “triggered beat” occurs during phase 4, which is _____________?

Answer 5

repolarization

Question 6

What are class II drugs?

Which part of the heart is sensitive to them?

And what is prolonged?

Answer 6

Beta Blockers

AV node

PR interval

Question 7

Which drug is classifed as Class III, but also has Class II B-blocking effects?

Answer 7

sotalol

Question 8

What contains mostly iodine by weight and is structurally similar to thyroxine?

Answer 8

Amiodarone

Question 9

What is the dominant effect of Amiodarone?

Answer 9

prolongation of the APD

Question 10

What are the 3 main ADRs of Amiodarone?

Answer 10

Druge induced Pulmonary Fibrois

Corneal deposits

Cough

HYPO thyroidism