Lipid anabolism Flashcards
What is lipogenesis?
Fatty acid synthesis
Where can lipogenesis occur?
Liver, kidney, mammary glands, adipose tissue
Where is the main organ for lipogenesis?
The liver - occurs when we take in too much energy
What happens if we take in too much energy?
Conversion to fatty acids and triglycerides in the liver
The free fatty acids are transported in the plasma bound to albumin
Triglycerides formed in the liver are transported to adipose tissue by VLDL for storage
is lipogenesis reductive or oxidative?
Reductive process, so it needs electrons
what is the precursor molecule for lipogenesis?
Acetyl - CoA
Where does synthesis of fatty acids from adetyl CoA occur?
In the cytoplasm of the liver
Where is acetyl-CoA generated?
In the mitochondria
How is acetyl groups moved into the cytoplasm from the matrix?
Via citrate - product of the TCA cycle
What is the first step in the synthesis of fatty acids from acetyl CoA?
The activation of acetyl Co A to malonyl-CoA by acetyl CoA carboxylase
what does fatty acid synthase do?
Makes only saturated straight chain fatty acids from malonyl-CoA, acetyl-CoA and NADPH
What does fatty acid synthase contain?
An acyl-carrier protein (ACP)
what is the electron doner for lipogenesis?
NADPH
When is the fatty acid released by fatty acid synthase?
16C is the longest it can make
what is the control of fatty acid metabolism?
Synthesis of fatty acids can only occur when there is lots of carbs and every available - or cells wouldnt expend ATP to make fatty acids
