Linking innate & adaptive immunity Module summary Flashcards
1
Q
Key cells
A
APCs –> DCs
T cells
-CD4
-CD8
2
Q
Key tissues
A
Lymph node
3
Q
Key molecules
A
Integrins/selectins
CCR7/CCL21 & CCL19
MHC class I & II
TCR complex
CO-receptors
-CD4
-CD8
Costimulatory molecules
Ligands
-On APC –> B7
-CD80/86
Receptors
-On T cells –> CD28
4
Q
Key concepts
A
Trafficking to Lymph node
Polygeny & polymorphism
Signaling
Antigen processing
T cell activation
Negative regulation of processes
5
Q
Antigen processing
A
Exogenous & endogenous
Exceptions
6
Q
T cell activation
A
Via signal 1 & 2
IL-2
Il-2R α
Exception: allorecognition
7
Q
Negative regulation of processes
A
Phosphatase & anergy