Linking innate & adaptive immunity Module summary Flashcards

1
Q

Key cells

A

APCs –> DCs

T cells
-CD4
-CD8

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2
Q

Key tissues

A

Lymph node

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3
Q

Key molecules

A

Integrins/selectins

CCR7/CCL21 & CCL19

MHC class I & II

TCR complex

CO-receptors
-CD4
-CD8

Costimulatory molecules

Ligands
-On APC –> B7
-CD80/86

Receptors
-On T cells –> CD28

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4
Q

Key concepts

A

Trafficking to Lymph node
Polygeny & polymorphism
Signaling
Antigen processing
T cell activation
Negative regulation of processes

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5
Q

Antigen processing

A

Exogenous & endogenous
Exceptions

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6
Q

T cell activation

A

Via signal 1 & 2
IL-2
Il-2R α
Exception: allorecognition

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7
Q

Negative regulation of processes

A

Phosphatase & anergy

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