lines of defence Flashcards
what are the components of the first line of defence
skin
mucous membranes
normal flora
explain the role of the skin in immune defence
closely packed kerainised skin cells assist in resistance to entry of pathogens.
explain the role of mucous membranes in immune defence
the mucous layers inhibits the entrance of many microorganisms. the mucous traps pathogens before entering the body further.
explain the role of normal flora in immune defence
normal flora suppresses growth of pathogenic bacteria by competing for essential nutrients
state the components of the second line of defence
inflammation
fever
phagocytes and natural killer cutes
protective proteins
describe how inflammation defends us from infection
when cells or tissues are damaged, histamines are released and and triggers vasodilation which causes the heat, redness and swelling. the blood vessels are now more permeable. blood clots form around an abscess to prevent spreading of infection which destroys the agent.
describe how fever defends us from infection
bacterial endotoxins induce fever by stimulating the hypothalamus and release prostaglandins that reset the hypothalamic thermostat of the body.
increased temp=faster reactions.
describe how phagocytes and natural killer cells defends us from infection
phagocytes are a type of white blood cell that is responsible for engulfing and absorbing bacteria and other small cells and particles. natural killer cells are capable of destroying tumour cells.
describe how protective proteins defends us from infection
the complement system is the first part of the immune system that meets invaders like bacteria.
they react directly with antigens and trigger inflammation, attract phagocytes, coat intruder cells to make more appetizing and kill intruders.
what is inflammation and what are some advantages of having an inflammatory response
when cells or tissues are damaged, histamines are released and and triggers vasodilation which causes the heat, redness and swelling. the blood vessels are now more permeable. blood clots form around an abscess to prevent spreading of infection which destroys the agent.
define antibody
a specific protein produces in response to a substance foreign to the body that reacts with the antigen to neutralize it or destroy it
define antigen
antigens are anything that triggers a specific immune response
what happens in the third line of defence
immunity is the ability for the body to specifically counteract foreign substances or organisms called antigens. immune responses involve the production of proteins called antibodies and specialized lymphocytes
what are the two different lymphocytes involved in immunity and where do they mature
t cells- thymus
b cells- bone marrow
what is celll mediated immunity
cell mediated immunity is depends on t cells and does not involve antibody production. their primary response is to intracellular infections (virus)