Linear IgA Disease Flashcards
1
Q
Where is the level of cleft?
A
Subepidermal
2
Q
What kind of infiltrate in LAD?
A
Neutrophilic
3
Q
What is the differential diagnosis?
A
- DH
- BP
- CP
4
Q
Is there mucous involvement?
A
- Yes
- 50% of cases Oral and conjunctival (scarring may occur as in CP)
5
Q
Is there association with enteropathy or HLA-B8?
A
No
6
Q
What is the percentage of remission after several years?
A
60%
7
Q
What does IgA target?
A
97-kD antigen
8
Q
Where is 97-kD antigen located?
A
Lamina lucida
9
Q
What other antigen does IgA target? (other than 97-kD)
A
LAD285
10
Q
Some patients have IgG and IgA directed to what antigen?
A
BP180
11
Q
Where are the antigenic targets expressed?
A
- Keratinocytes
- Fibroblasts
12
Q
What is different about drug-induced linear IgA dermatosis?
A
- Eruption is self-limited
- Less mucosal involvement
- No detectable circulating antibodies
13
Q
What drugs cause drug-induced linear IgA dermatosis?
A
- Vancomycin
- Lithium
- Amiodarone
- Lasix
- Captopril
- Penicillin
- Phenytoin
14
Q
What antigens are identified in drug-induced LAD?
A
- 97-kD
- BP180
- BP230
15
Q
What is seen on DIF?
A
- Linear pattern of IgA at BMZ
- Lack C3
